{
  "abstract": "Introduction\n\nCorticosteroids are widely used in COVID-19 pneumonia; however, the optimal regimen remains uncertain. We compared clinical outcomes between pulse-dose methylprednisolone and prolonged low-dose dexamethasone in hospitalized patients with COVID-19 pneumonia.Methods\n\nIn this retrospective cohort study, adult patients hospitalized with COVID-19 pneumonia (18 April-30 August 2021), who received either pulse-dose methylprednisolone or prolonged low-dose dexamethasone, were compared regarding 28-day mortality, in-hospital mortality, and treatment-free days. Multivariable Cox regression and propensity score matching (PSM) were used to adjust for confounding.Results\n\nAmong 460 patients (269 pulse-dose methylprednisolone, 191 prolonged low-dose dexamethasone), no significant difference in 28-day mortality was observed in multivariable analysis (aHR: 1.51; 95% CI: 0.74-3.09, p = 0.26). After PSM, 28-day mortality remained similar (HR: 1.40; 95% CI: 0.64-3.06; p = 0.38), although a trend toward higher in-hospital mortality was noted with pulse-dose methylprednisolone (HR: 2.07; 95% CI: 0.96-4.42; p = 0.06).Conclusion\n\nPulse-dose methylprednisolone was not associated with a significant difference in 28-day mortality compared with prolonged low-dose dexamethasone. A trend toward higher in-hospital mortality was observed with pulse-dose methylprednisolone, warranting cautious interpretation due to potential residual confounding.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Emergency Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.",
    "Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, 10540, Thailand."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Pitsucha Sanguanwit"
    },
    {
      "affs": [
        0
      ],
      "name": "Poonyanutch Rinprasertmeechai"
    },
    {
      "affs": [
        1
      ],
      "name": "Sittichok Leela-Amornsin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c3asx7vak0ky6.bib",
  "cited_by": 0,
  "doi": "10.22037/aaem.v14i1.3063",
  "fulltext_url": "https://europepmc.org/articles/PMC13704293",
  "id": "c3asx7vak0ky6",
  "issns": [
    "2645-4904"
  ],
  "landing_url": "https://europepmc.org/article/MED/42936320",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2725|COVID-19 Clinical Research Studies"
    ]
  ],
  "openalex": "W7213338875",
  "pdf_url": "https://europepmc.org/articles/PMC13704293?pdf=render",
  "pmcid": "PMC13704293",
  "pmid": "42936320",
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c3asx7vak0ky6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42936320",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42936320"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|COVID-19 Clinical Research Studies",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Comparative 28-day Outcomes of Pulse-Dose Methylprednisolone versus Prolonged Low-Dose Dexamethasone in Hospitalized COVID-19 Pneumonia: A Cohort Study.",
  "title_text": "Comparative 28-day Outcomes of Pulse-Dose Methylprednisolone versus Prolonged Low-Dose Dexamethasone in Hospitalized COVID-19 Pneumonia: A Cohort Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/c3asx7vak0ky6",
  "venue": "Archives of academic emergency medicine",
  "versions": []
}