{
  "abstract": "This study evaluated the effects of Tribolium castaneum (TC) infestation on the quality of Citri Reticulatae Pericarpium (Chenpi) and identified potential infestation-related markers. Overall, infestation significantly reduced the contents of phenolic acids and flavonoids, as well as antioxidant activity. Untargeted UPLC-MS analysis annotated 1162 metabolites. Using VIP > 1, FC > 1.5 or < 0.66, and P < 0.05 (uncorrected) as screening criteria, 53 and 134 differential metabolites were identified in the 50 TC vs No TC and 100 TC vs No TC comparisons, respectively, with organoheterocyclic compounds showing the most pronounced increase in abundance. Enrichment analysis revealed that purine metabolism was significantly upregulated after infestation. In this pathway, uric acid, hypoxanthine, and xanthine accumulated markedly with increasing TC density and showed significant correlations with the quality deterioration of infested Chenpi. Therefore, these three purine-related metabolites were proposed as candidate markers associated with TC infestation.",
  "abstract_shown": true,
  "affiliations": [
    "School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China",
    "Shandong Academy of Chinese Medicine, Jinan 250014, China",
    "State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping/College of Plant Protection, Henan Agricultural University, Zhengzhou 450046, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yunxia Cheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Meng Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiujuan Ma"
    },
    {
      "affs": [
        2
      ],
      "name": "Jinrong Tang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c3c12sx26e486.bib",
  "cited_by": 0,
  "doi": "10.1016/j.fochx.2026.104686",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737710/",
  "id": "c3c12sx26e486",
  "issns": [
    "2590-1575"
  ],
  "landing_url": "https://doi.org/10.1016/j.fochx.2026.104686",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2707|Traditional Chinese Medicine Analysis"
    ]
  ],
  "openalex": "W7223565138",
  "pdf_url": null,
  "pmcid": "PMC13737710",
  "pmid": "42992016",
  "published": "2026-10-25",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/c3c12sx26e486.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:50Z",
      "native_id": "PMC13737710",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.fochx.2026.104686"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2707|Traditional Chinese Medicine Analysis",
      "subfield": "general"
    }
  ],
  "title": "Metabolomic screening integrated with quality evaluation to pinpoint candidate markers in Chenpi infested by Tribolium castaneum",
  "title_text": "Metabolomic screening integrated with quality evaluation to pinpoint candidate markers in Chenpi infested by Tribolium castaneum",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:50Z",
  "url": "https://research.draconitic.com/paper/c3c12sx26e486",
  "venue": "Food Chemistry: X",
  "versions": []
}