{
  "abstract": "Follicular lymphoma (FL) is the second most common lymphoma subtype in Europe, with a median age at diagnosis of 60-65 years. It is generally considered an indolent disease, and the median overall survival at diagnosis now likely exceeds 20 years. However, considerable heterogeneity exists. Diagnosis requires adequate biopsy material and a specialized hematopathologist. Staging and prognosis rely on positron emission tomography (PET)-computed tomography (CT). Prognostication at diagnosis is based on several validated clinical prognostic scores. Localized disease is usually treated with radiotherapy ± Rituximab. The treatment of disseminated disease includes active surveillance (or in selected cases Rituximab monotherapy) for low-tumor burden patients, and most often immunochemotherapy (or in selected cases chemo-free therapeutic options), ±antibody maintenance in high-tumor burden patients. For relapsed or refractory disease, treatment with Rituximab-Lenalidomide combination ± Tafasitamab or Epcoritamab from the first relapse and single-agent bispecific antibodies, chimeric antigen receptor T-cell therapy (CAR-T) cells, and Zanubrutinib-Obinutuzumab after second relapse should be prioritized over immunochemotherapy. Given the long natural history and risk of relapse, careful follow-up is an important part of patient management. Patients should be actively involved in decision-making. In this guideline, we present current evidence-based recommendations for diagnosis, staging, treatment, and follow-up.",
  "abstract_shown": true,
  "affiliations": [
    "Dipartimento di Medicina of Traslazionale Università del Piemonte Orientale Alessandria Italy.",
    "IRCCS, Azienda Ospedaliero-Universitaria Santi Antonio e Biagio e Cesare Arrigo Alessandria Italy.",
    "Lymphoma Coalition Ontario Canada.",
    "ELLyE - Patient Organization Paris France.",
    "Department of Radiation Oncology University Hospital of Heidelberg Heidelberg Germany.",
    "Department of Pathology University Hospital Schleswig-Holstein Kiel Germany.",
    "University of Helsinki and Helsinki University Hospital Helsinki Finland.",
    "Division of Cancer Sciences The University of Manchester and The Christie NHS Foundation Trust Manchester United Kingdom.",
    "Department of Hematology Hospital Clínic de Barcelona Barcelona Spain.",
    "Hematology Azienda USL IRCCS of Reggio Emilia Reggio Emilia Italy.",
    "CHIMOMO Department University of Modena and Reggio Emilia Reggio Emilia Italy.",
    "Centre Hospitalier Universitaire (CHU) Lille, Université de Lille, Groupe de Recherche sur les Formes Injectables et les Technologies Associées (ULR 7365-GRITA) Lille France.",
    "Centre for Haemato-Oncology, Barts Cancer Institute Queen Mary University of London London United Kingdom.",
    "Maria Sklodowska-Curie National Research Institute of Oncology Warsaw Poland.",
    "Université Paris Cité & Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Hemato-oncologie Paris France.",
    "Department of Hematology Amsterdam UMC, Location VUmc Amsterdam The Netherlands.",
    "First Faculty of Medicine, Charles University Hospital Prague Czech Republic.",
    "Concord Repatriation General Hospital University of Sydney Sydney New South Wales Australia.",
    "Department of Internal Medicine, Division of Hematology Istanbul University - Cerrahpaşa, Cerrahpaşa Medical Faculty Istanbul Türkiye.",
    "Department of Medicine III LMU University Hospital Munich Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Marco Ladetto",
      "orcid": "0000-0002-8283-2681"
    },
    {
      "affs": [
        2
      ],
      "name": "Natacha Bolaños"
    },
    {
      "affs": [
        3
      ],
      "name": "Guy Bouguet"
    },
    {
      "affs": [
        4
      ],
      "name": "Klaus Herfarth",
      "orcid": "0000-0002-6325-4193"
    },
    {
      "affs": [
        5
      ],
      "name": "Wolfram Klapper",
      "orcid": "0000-0001-7208-4117"
    },
    {
      "affs": [
        6
      ],
      "name": "Sirpa Leppa",
      "orcid": "0000-0002-8265-511X"
    },
    {
      "affs": [
        7
      ],
      "name": "Kim Linton"
    },
    {
      "affs": [
        8
      ],
      "name": "Armando Lopez-Guillermo"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Stefano Luminari",
      "orcid": "0000-0001-8446-2285"
    },
    {
      "affs": [
        11
      ],
      "name": "Franck Morschhauser",
      "orcid": "0000-0002-3714-9824"
    },
    {
      "affs": [
        12
      ],
      "name": "Jessica Okosun",
      "orcid": "0000-0001-6021-5044"
    },
    {
      "affs": [
        13
      ],
      "name": "Ewa Paszkiewicz-Kozik",
      "orcid": "0000-0003-2629-3932"
    },
    {
      "affs": [
        14
      ],
      "name": "Catherine Thieblemont"
    },
    {
      "affs": [
        15
      ],
      "name": "Sanne Helene Tonino"
    },
    {
      "affs": [
        16
      ],
      "name": "Marek Trneny",
      "orcid": "0000-0002-6952-6073"
    },
    {
      "affs": [
        17
      ],
      "name": "Judith Trotman",
      "orcid": "0000-0001-8009-4593"
    },
    {
      "affs": [
        18
      ],
      "name": "Umut Yilmaz",
      "orcid": "0000-0002-8672-0679"
    },
    {
      "affs": [
        19
      ],
      "name": "Martin Dreyling"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c3f4tbfdtzxx8.bib",
  "cited_by": 0,
  "doi": "10.1002/hem3.70507",
  "fulltext_url": "https://europepmc.org/articles/PMC13680546",
  "id": "c3f4tbfdtzxx8",
  "issns": [
    "2572-9241"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903357",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
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  "openalex": "W7222914089",
  "pdf_url": "https://europepmc.org/articles/PMC13680546?pdf=render",
  "pmcid": "PMC13680546",
  "pmid": "42903357",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c3f4tbfdtzxx8.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903357",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903357"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Newly diagnosed and relapsed follicular lymphoma: EHA Clinical Practice Guidelines for diagnosis, treatment, and follow-up.",
  "title_text": "Newly diagnosed and relapsed follicular lymphoma: EHA Clinical Practice Guidelines for diagnosis, treatment, and follow-up.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/c3f4tbfdtzxx8",
  "venue": "HemaSphere",
  "versions": []
}