{
  "abstract": "目的探讨在甲状腺功能正常的2型糖尿病患者中甲状腺敏感指数与骨质疏松（OP）的相关性。方法回顾性研究2023年1月至2025年12月于郑州大学第五附属医院内分泌科住院的甲状腺功能正常的2型糖尿病患者，依据骨密度测定结果分为骨质疏松组（OP组）及非骨质疏松组（非OP组），探讨外周及中枢甲状腺敏感指数与OP风险的相关性。结果与非OP组相比，OP组患者在生活方式、性别、体重指数、年龄、糖尿病病程、糖脂代谢方面均存在统计学差异。多因素 Logistic 回归分析结果提示外周甲状腺敏感指数FT3/FT4未显示出与OP风险的显著相关性，但中枢甲状腺敏感指数促甲状腺激素指数（TSHI）、促甲状腺激素抵抗指数（TT4RI）、甲状腺反馈分位指数（TFQI）与OP风险均呈显著负相关，经调整混杂因素后这种相关性仍然存在（P值均<0.05）。采用限制性立方样条（RCS）函数对甲状腺敏感指数相关指标与OP风险之间的剂量-反应关系进行建模分析显示，各相关指标与OP风险之间均呈现显著的线性关系（所有非线性检验P值均>0.05）。进一步亚组分析及交互作用分析提示TSHI、TT4RI 和 TFQI 在男性中作用更为显著（P值均<0.05）。结论2型糖尿病患者中枢甲状腺激素敏感性增高可能与OP风险增加密切相关。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "饶小娟"
    },
    {
      "name": "解丽然"
    },
    {
      "name": "史双伟"
    },
    {
      "name": "方一凡"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c3vdtzvtmdg2f.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.016",
  "id": "c3vdtzvtmdg2f",
  "issns": [
    "1007-4287"
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  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.016",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/c3vdtzvtmdg2f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:47Z",
      "native_id": "af8dbdf8475544f5b140ab15909b13b3",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.016"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "2型糖尿病患者甲状腺激素敏感性与骨质疏松的相关性研究",
  "title_text": "2型糖尿病患者甲状腺激素敏感性与骨质疏松的相关性研究",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:47Z",
  "url": "https://research.draconitic.com/paper/c3vdtzvtmdg2f",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}