{
  "abstract": "Background\n\nReperfusion injury (RI) is a major contributor to poor outcomes after successful recanalization in anterior circulation-large vessel occlusion. White matter hyperintensities (WMH) reflect chronic microvascular injury and are often associated with blood-brain barrier dysfunction or cerebral autoregulation impairment and may increase vulnerability to RI. We examined the association between WMH severity, RI, and clinical outcomes after successful recanalization.Methods\n\nWe retrospectively analyzed 236 patients with anterior circulation-large vessel occlusion who achieved modified Thrombolysis in Cerebral Infarction ≥2b. WMH severity was assessed using the Fazekas scale and dichotomized into absent-to-mild (score 0-3) and severe (score 4-6). RI was defined as parenchymal hematoma or malignant cerebral edema. Risk ratio (RR) was calculated, and causal mediation analysis was performed to assess the indirect effect of WMH on poor 90-day functional outcome (modified Rankin Scale of 3-6).Results\n\nSevere WMH burden was present in 60 (25.4%) cases, RI occurred in 40 (16.9%) cases, and 128 (54.2%) cases had poor outcomes. Severe WMH was associated with an increased risk of RI (RR, 3.52 [95% CI, 1.97-6.29]; P<0.001). RI was independently associated with poor outcome (RR, 1.28 [95% CI, 1.01-1.62]; P=0.042), whereas WMH alone was not. In mediation analysis, severe WMH burden was not associated with poor outcome in terms of the total effect (RR, 1.02 [95% CI, 0.78-1.31]; P=0.744), but there was a significant indirect effect of severe WMH on poor outcome through RI (RR, 1.13 [95% CI, 1.04-1.30]; P=0.004).Conclusions\n\nSevere WMH burden increases the risk of RI, which in turn adversely affects functional outcomes despite successful recanalization. WMH assessment may aid in identifying patients at higher risk of RI and support clinical risk stratification in anterior circulation-large vessel occlusion.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, Yamaguchi University School of Medicine, Japan (T.N., F.O., S.F., N.M., A.K., H.I.).",
    "Innovation Center for Translational Research, National Center for Geriatrics and Gerontology, Japan (R.K.)."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Takuma Nishimoto",
      "orcid": "0000-0002-1224-8711"
    },
    {
      "affs": [
        0
      ],
      "name": "Fumiaki Oka",
      "orcid": "0000-0002-1319-425X"
    },
    {
      "affs": [
        1
      ],
      "name": "Reo Kawano"
    },
    {
      "affs": [
        0
      ],
      "name": "Shunsuke Fujitsuku"
    },
    {
      "affs": [
        0
      ],
      "name": "Naomasa Mori",
      "orcid": "0009-0000-9481-4491"
    },
    {
      "affs": [
        0
      ],
      "name": "Akiko Kawano",
      "orcid": "0000-0002-0225-0666"
    },
    {
      "affs": [
        0
      ],
      "name": "Hideyuki Ishihara",
      "orcid": "0000-0002-0208-2412"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c3vebgvjfycz6.bib",
  "cited_by": 0,
  "doi": "10.1161/svin.126.002417",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727217/?tool=EBI",
  "id": "c3vebgvjfycz6",
  "issns": [
    "2694-5746"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727217",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "heading",
      "10178"
    ],
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
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  "openalex": "W7216317932",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727217/pdf/?tool=EBI",
  "pmcid": "PMC13727217",
  "pmid": "42974599",
  "published": "2026-10-02",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/c3vebgvjfycz6.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13727217",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727217"
    },
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42974599",
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      "url": "https://doi.org/10.1161/svin.126.002417"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
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  ],
  "title": "Impact of White Matter Hyperintensities on Reperfusion Injury and Clinical Outcome After Successful Recanalization",
  "title_text": "Impact of White Matter Hyperintensities on Reperfusion Injury and Clinical Outcome After Successful Recanalization",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:56Z",
  "url": "https://research.draconitic.com/paper/c3vebgvjfycz6",
  "venue": "Stroke (Hoboken, N.J.)",
  "versions": []
}