{
  "abstract": "系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，其发病机制与免疫细胞功能紊乱关系密切。近年来研究表明，免疫代谢重编程被认为是驱动SLE免疫失衡的重要机制。T细胞、B细胞和巨噬细胞在疾病过程中均表现出糖代谢、脂质代谢和氨基酸代谢的异常改变，并通过影响细胞活化、分化、炎症因子产生及效应功能，参与SLE的发生发展。例如，糖酵解增强促进致病性T细胞分化和巨噬细胞炎症活化，脂质代谢异常驱动Th17偏移、B细胞异常活化及巨噬细胞促炎极化，氨基酸代谢紊乱则通过调控哺乳动物雷帕霉素靶蛋白（MTOR）、表观遗传修饰及色氨酸代谢通路参与免疫失衡。靶向葡萄糖转运体1（GLUT1）、脂肪酸合酶（FASN）、氨基酸转运蛋白1（LAT-1）等代谢节点的干预已在实验研究中显示出缓解炎症、降低自身抗体水平和改善肾损伤的潜力。本文围绕SLE中关键免疫细胞的代谢重编程特征、分子机制及潜在治疗靶点进行综述，为SLE的机制研究和精准治疗提供了参考。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "杨盛文"
    },
    {
      "name": "郝苗"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c3w43ng4vqvqj.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.023",
  "id": "c3w43ng4vqvqj",
  "issns": [
    "1007-4287"
  ],
  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.023",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/c3w43ng4vqvqj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:44Z",
      "native_id": "34ebda421db34d8eb9082e7992ff7f71",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.023"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "系统性红斑狼疮中免疫细胞的代谢重编程：机制与治疗靶点",
  "title_text": "系统性红斑狼疮中免疫细胞的代谢重编程：机制与治疗靶点",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:44Z",
  "url": "https://research.draconitic.com/paper/c3w43ng4vqvqj",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}