{
  "abstract": "Brain tumors interact bidirectionally with neural circuits, but direct electrophysiological evidence in the human brain across tumor types remains limited. We analyzed intraoperative clinical, mesoscale, and high-density surface electroencephalography recordings from 100 participants undergoing tumor resection, epilepsy surgery, or deep brain stimulation. Population-averaged measures poorly separated diagnoses, whereas spatially resolved aperiodic exponent and high-gamma activity varied with both tumor distance and nearby tumor volume fraction across scales. Gradients differed among IDH-mutant glioma, IDH-wildtype glioblastoma, and metastases. Connectivity further distinguished infiltrative gliomas: beta coherence across tumor-brain connections was reduced in IDH-mutant tumors (p=0.0006; Kruskal-Wallis; mean coherence: tumor-brain 0.26, tumor-tumor 0.44, brain-brain 0.34), unlike IDH-wildtype tumors or metastases. Physiological abnormalities extended into radiographically normal-appearing brain, indicating tumor-type-dependent physiological signatures that may dynamically map the tumor-brain interface complementing structural imaging, with future possibilities as a spatial biomarker of tumor infiltration and network organization in humans.",
  "abstract_shown": true,
  "affiliations": [
    "Massachusetts General Hospital"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 39,
  "authors": [
    {
      "name": "T. Nelson"
    },
    {
      "name": "B. Hsueh"
    },
    {
      "name": "P. Hadar"
    },
    {
      "name": "I. Das"
    },
    {
      "name": "B. F. Coughlin"
    },
    {
      "name": "A. Mandal"
    },
    {
      "name": "T. Wilson"
    },
    {
      "name": "E. Peng"
    },
    {
      "name": "A. S. Perley"
    },
    {
      "name": "H. Rabbani"
    },
    {
      "name": "R. Ciordia"
    },
    {
      "name": "J. Zou"
    },
    {
      "name": "A. Bush"
    },
    {
      "name": "M. Vissani"
    },
    {
      "name": "H. Ghaith"
    },
    {
      "name": "J. Cahill"
    },
    {
      "name": "J. C. Yang"
    },
    {
      "name": "W. Munoz"
    },
    {
      "name": "E. F. Torio"
    },
    {
      "name": "A. C. Glaser"
    },
    {
      "name": "J. D. Bernstock"
    },
    {
      "name": "K. L. Collins"
    },
    {
      "name": "D. R. Cleary"
    },
    {
      "name": "H. K. Tiwana"
    },
    {
      "name": "A. J. Golby"
    },
    {
      "name": "P. S. Jones"
    },
    {
      "name": "B. D. Choi"
    },
    {
      "name": "B. V. Nahed"
    },
    {
      "name": "A. M. Raslan"
    },
    {
      "name": "Z. M. Williams"
    },
    {
      "name": "S. A. Dayeh"
    },
    {
      "name": "P. Nanda"
    },
    {
      "name": "R. M. Richardson"
    },
    {
      "name": "W. L. Bi"
    },
    {
      "name": "S. Tobochnik"
    },
    {
      "name": "D. P. Cahill"
    },
    {
      "name": "G. P. Dunn"
    },
    {
      "name": "S. S. Cash"
    },
    {
      "affs": [
        0
      ],
      "name": "A. C. Paulk"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c40jvnabt5bpx.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.05.26364665",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364665v1.full",
  "id": "c40jvnabt5bpx",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364665v1",
  "language": null,
  "licence": "CC-BY-ND",
  "licence_label": "CC BY-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7220964892",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364665v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c40jvnabt5bpx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:24Z",
      "native_id": "10.64898/2026.10.05.26364665",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.05.26364665v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Spatial Neurophysiological Gradients at High Resolution Differentiate Tumor Types in the Human Cortex at the Tumor-Brain Interface",
  "title_text": "Spatial Neurophysiological Gradients at High Resolution Differentiate Tumor Types in the Human Cortex at the Tumor-Brain Interface",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:24Z",
  "url": "https://research.draconitic.com/paper/c40jvnabt5bpx",
  "venue": "medRxiv",
  "versions": []
}