{
  "abstract": "Introduction: Autologous hematopoietic stem cell transplantation is a standard treatment for lymphomas and multiple myeloma. Efficient mobilization and collection of CD34+ cells are essential to reduce costs, procedure time, and patient burden. Identifying predictors of successful collection in a single leukapheresis session is particularly relevant in resource-limited settings. Casuistic: This study included 103 adult patients undergoing stem cell mobilization and collection between 2019 and 2023 at a tertiary center. The cohort comprised 54.4% men, with a mean age of 54.6 years. Indications were lymphomas (48.5%), multiple myeloma (47.6%), and other plasma cell disorders (3.9%). Methodology: A retrospective, single-center study was conducted using clinical, laboratory, and procedural data. Mobilization was performed with G-CSF alone or combined with plerixafor. The primary endpoint was successful collection in a single leukapheresis session, defined as ≥ 2 × 10⁶ CD34+ cells/kg. ROC curve analysis determined the optimal peripheral CD34+ cutoff. Factors associated with the outcome were assessed using univariate and multivariate analyses. Results: A total of 149 leukapheresis procedures were performed. Single-session success was achieved in 61.2% of patients. The mean peripheral CD34+ count on the first collection day was 39 cells/mm³. A cutoff > 33 cells/mm³ predicted successful single-session collection. In multivariate analysis, the use of G-CSF plus plerixafor (OR 2.48; p = 0.045) and higher leukocyte count on the collection day (OR 2.48; p = 0.030) were independently associated with success. The mean CD34+ yield on the first day was 4.4 × 10⁶ cells/kg, with viability > 99%. The mean engraftment time was 11.4 days. Conclusions: A peripheral CD34+ count > 33 cells/mm³ is a robust predictor of successful single session leukapheresis. The addition of plerixafor and higher leukocyte counts improve mobilization outcomes. These findings support more efficient and individualized mobilization strategies, optimizing resource utilization and improving patient outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Rede Américas, São Paulo, SP, Brazil",
    "Grupo Pulsa São Paulo, São Paulo, SP, Brazil"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Breno Aires Cadiele Oliana REICHERT"
    },
    {
      "affs": [
        0
      ],
      "name": "Celso ARRAIS"
    },
    {
      "affs": [
        1
      ],
      "name": "Raquel Valverde SOUSA"
    },
    {
      "affs": [
        1
      ],
      "name": "Renata Priscila GOMES"
    },
    {
      "affs": [
        1
      ],
      "name": "Waldely Veneziani CALHEIROS"
    },
    {
      "affs": [
        1
      ],
      "name": "Erica Mioto Braz MERCHAN"
    },
    {
      "affs": [
        1
      ],
      "name": "Mirianceli Coelho MENDONÇA"
    },
    {
      "affs": [
        1
      ],
      "name": "Cesar De Almeida NETO"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c4jt3rqt3kb8x.bib",
  "cited_by": 0,
  "doi": "10.1016/j.htct.2026.106900",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2531137926006474",
  "id": "c4jt3rqt3kb8x",
  "issns": [
    "2531-1379",
    "2531-1387"
  ],
  "landing_url": "https://doi.org/10.1016/j.htct.2026.106900",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC633-647.5"
    ],
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W7223110901",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/c4jt3rqt3kb8x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:20Z",
      "native_id": "82d714c3706c4e6089223ad00b772d41",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.htct.2026.106900"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC633-647.5",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "PREDICTIVE FACTORS FOR HEMATOPOIETIC STEM CELL MOBILIZATION IN AUTOLOGOUS TRANSPLANTATION: DEFINING A PERIPHERAL CD34+ CUTOFF FOR SINGLE-SESSION SUCCESS",
  "title_text": "PREDICTIVE FACTORS FOR HEMATOPOIETIC STEM CELL MOBILIZATION IN AUTOLOGOUS TRANSPLANTATION: DEFINING A PERIPHERAL CD34+ CUTOFF FOR SINGLE-SESSION SUCCESS",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:20Z",
  "url": "https://research.draconitic.com/paper/c4jt3rqt3kb8x",
  "venue": "Hematology, Transfusion and Cell Therapy",
  "versions": []
}