{
  "abstract": "Background: Hip fractures remain a challenge for patients on direct oral anticoagulants. In a population-based study, we wanted to evaluate the impact of DOACS and its concentration on postoperative mortality after hip fracture surgery. Methods: In a retrospective, monocenter study, we included all patients aged >65 yrs at a geriatric perioperative unit, admitted for hip fracture, treated with or without DOACs, and similarly managed with early surgery. Patients were divided into No-DOACs or DOACs groups. According to plasma DOAC concentrations on the day of surgery, DAOCs was divided into subgroup: <30, 3050, 5180 ng.mL1. Plasma of DOACs were analysed as long as the concentrations measured were >30 ng.mL1. The primary endpoint was mortality up to Day 30. Patient blood management and plasma assays were recorded. Results: From January 2022 to September 2023, 117 patients were analyzed in the DOACs group and 468 in the No-DOACs group. Patients with DOACs were most often operated on with a one-day delay (P < 0.05). Non DAOC group presented lower mortality at 30 day (P < 0.01). Up to Day 180, mortality rates were lower in the No-DOACs group with a 0.34 median hazard-risk [0.190.59]. Transfusion rates were similar in No-DOACs and DOACs groups (43 versus 48%, P = 0.55). Subgroups (<30, 3050, 50–80 ng.mL1) presented similar outcomes (transfusion, mortality). Conclusion: DOACs were associated with higher mortality. A level of up to < 80 ng.mL1 does not appear to make any difference to transfusion compared with no DOAC.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Yann Gricourt"
    },
    {
      "name": "Mikael Perin"
    },
    {
      "name": "Nicolas Basseres"
    },
    {
      "name": "Laetitia Geronimi"
    },
    {
      "name": "Jean-Yves Lefrant"
    },
    {
      "name": "Myriam Mezzarobba"
    },
    {
      "name": "Mathias Chéa"
    },
    {
      "name": "Jean Christophe Gris"
    },
    {
      "name": "Philippe Cuvillon"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c4jxztd8b5810.bib",
  "cited_by": 1,
  "doi": "10.1016/j.accpm.2025.101616",
  "fulltext_url": null,
  "id": "c4jxztd8b5810",
  "issns": [
    "2352-5568"
  ],
  "landing_url": "https://hal.science/hal-05829685v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "1.sdv.sp"
    ],
    [
      "hal",
      "2.sdv.mhep.hem"
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    [
      "hal",
      "2.sdv.sp.pharma"
    ],
    [
      "openalex",
      "2746|Hip and Femur Fractures"
    ]
  ],
  "openalex": "W4414826547",
  "pdf_url": "https://hal.science/hal-05829685/document",
  "pmcid": null,
  "pmid": "41052671",
  "published": "2026-10-21",
  "publisher": "Elsevier Masson",
  "ris": "https://research.draconitic.com/paper/c4jxztd8b5810.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:00Z",
      "native_id": "hal-05829685",
      "source": "hal",
      "url": "https://hal.science/hal-05829685v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.sp",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Impact of direct oral anticoagulant treatment on management and outcomes of patients with hip fractures by monitoring assays. A population-based study of a cohort from the Geriatric Perioperative Unit",
  "title_text": "Impact of direct oral anticoagulant treatment on management and outcomes of patients with hip fractures by monitoring assays. A population-based study of a cohort from the Geriatric Perioperative Unit",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:00Z",
  "url": "https://research.draconitic.com/paper/c4jxztd8b5810",
  "venue": "Anaesthesia Critical Care & Pain Medicine",
  "versions": []
}