{
  "abstract": "This study aimed to evaluate 3-methyladenine (3-MA) as a post-exposure intervention for arsenic-associated hepatic injury and fibrotic remodeling, motivated by its reported antifibrotic effects. Female C57BL/6J mice received sodium arsenite via drinking water for 20 weeks at a nominal target dose of 1.08 mg/kg body weight/day, based on our group's previous experiments. The remaining exposed mice were randomized to intraperitoneal vehicle (n = 8) or 3-MA (n = 9; 5 μg/g body weight), administered twice weekly for 4 weeks after arsenic withdrawal. The 3-MA dose and frequency were based on a published carbon tetrachloride-induced fibrosis study. Serum markers, liver histology, and hepatic proteins were assessed. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) trajectories differed between groups, with lower Day-28 activities after 3-MA; the ALT difference persisted after baseline adjustment (p = 0.0011). Day-28 serum hyaluronic acid, N-terminal propeptide of type III procollagen, tumor necrosis factor-α, collagen volume fraction, and α-smooth muscle actin immunoreactivity were also lower than with vehicle. These differences were accompanied by changes in nuclear factor-kappa B- and autophagy-related proteins. Post-exposure 3-MA was associated with lower hepatic injury and fibrotic remodeling indices, but an autophagy-dependent mechanism and within-animal fibrosis regression were not established.",
  "abstract_shown": true,
  "affiliations": [
    "School of Public Health, Chongqing Medical University, Chongqing 401331, China.",
    "School of Public Health, Xinjiang Second Medical College, Karamay 834000, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu Hui"
    },
    {
      "affs": [
        0
      ],
      "name": "Qin Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c4n2g6zn8mcd6.bib",
  "cited_by": 0,
  "doi": "10.3390/toxics14100873",
  "fulltext_url": "https://europepmc.org/articles/PMC13709370",
  "id": "c4n2g6zn8mcd6",
  "issns": [
    "2305-6304"
  ],
  "landing_url": "https://europepmc.org/article/MED/42931660",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2304|Arsenic contamination and mitigation"
    ]
  ],
  "openalex": "W7214966282",
  "pdf_url": "https://europepmc.org/articles/PMC13709370?pdf=render",
  "pmcid": "PMC13709370",
  "pmid": "42931660",
  "published": "2026-09-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c4n2g6zn8mcd6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42931660",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42931660"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2304|Arsenic contamination and mitigation",
      "subfield": "environmental"
    }
  ],
  "title": "Post-Exposure 3-Methyladenine Is Associated with Lower Indices of Hepatic Injury and Fibrotic Remodeling After Chronic Sodium Arsenite Exposure in Mice.",
  "title_text": "Post-Exposure 3-Methyladenine Is Associated with Lower Indices of Hepatic Injury and Fibrotic Remodeling After Chronic Sodium Arsenite Exposure in Mice.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/c4n2g6zn8mcd6",
  "venue": "Toxics",
  "versions": []
}