{
  "abstract": "We report an efficient and practical strategy for the synthesis of bromo-substituted 2-azetines bearing a β-naphthol moiety. The reaction proceeds via the formation of highly reactive vinylidene ortho-quinone methide (VQM) intermediates, followed by intramolecular bromocyclization to afford highly strained 2-azetines under mild conditions. Notably, the cyclization step is significantly facilitated by catalytic Schreiner's urea. This protocol is readily scalable, and the strategically incorporated bromo group in the product provides a convenient handle for further derivatization.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Aoto Suzuki"
    },
    {
      "name": "Ryo Hirokawa"
    },
    {
      "name": "Hayate Takeuchi"
    },
    {
      "name": "Kenji Yamashita"
    },
    {
      "name": "Yoshitaka Hamashima"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c4r9kpf23n2ar.bib",
  "cited_by": 0,
  "doi": "10.1248/cpb.c26-00411",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00411/_article",
  "id": "c4r9kpf23n2ar",
  "issns": [
    "1347-5223",
    "0009-2363"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00411/_article",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "chemistry/medicinal"
    ],
    [
      "openalex",
      "1605|Organic Chemistry Synthesis Methods"
    ]
  ],
  "openalex": "W7214934309",
  "pdf_url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00411/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c4r9kpf23n2ar.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "10.1248/cpb.c26-00411",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00411/_article"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organic Chemistry Synthesis Methods",
      "subfield": "organic"
    }
  ],
  "title": "Efficient and Practical Synthesis of β-Naphthol-Substituted 2-Azetines via Vinylidene ortho-Quinone Methide (VQM) Intermediates",
  "title_text": "Efficient and Practical Synthesis of β-Naphthol-Substituted 2-Azetines via Vinylidene ortho-Quinone Methide (VQM) Intermediates",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/c4r9kpf23n2ar",
  "venue": "Chemical and Pharmaceutical Bulletin",
  "versions": []
}