{
  "abstract": "Hepatic encephalopathy remains an underserved complication of chronic liver disease. Reliable diagnostic and prognostic biomarkers linked to disease pathophysiology are currently lacking, as are options for treatment that reduce mortality beyond lactulose and rifaximin. However, with the advent of high-throughput sequencing and multi-omics techniques to interrogate microbial taxonomy and metabolic pathways, our understanding of the gut-liver-brain-axis has moved beyond the ammonia-inflammation hypothesis. This review summarises recent studies that have aimed to characterise the role of the gut-liver-brain axis in hepatic encephalopathy and how this can be leveraged to create novel diagnostic, prognostic and therapeutic approaches.",
  "abstract_shown": true,
  "affiliations": [
    "Corresponding author. Address: Roger Williams Institute of Liver Studies, King’s College London, UK.",
    "Roger Williams Institute of Liver Studies, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London, UK"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yevedzo Ntuli"
    },
    {
      "affs": [
        1
      ],
      "name": "Maria Nehme Ibrahimi"
    },
    {
      "affs": [
        1
      ],
      "name": "Victoria Tatiana Kronsten"
    },
    {
      "affs": [
        1
      ],
      "name": "Debbie Lindsay Shawcross"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c4re1dfmm95rc.bib",
  "cited_by": 1,
  "doi": "10.1016/j.jhepr.2026.102022",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2589555926002934",
  "id": "c4re1dfmm95rc",
  "issns": [
    "2589-5559"
  ],
  "landing_url": "https://doi.org/10.1016/j.jhepr.2026.102022",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC799-869"
    ],
    [
      "openalex",
      "2721|Liver Disease and Transplantation"
    ]
  ],
  "openalex": "W7207573249",
  "pdf_url": "https://www.jhep-reports.eu/article/S2589-5559(26)00293-4/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/c4re1dfmm95rc.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T14:21:05Z",
      "native_id": "0c5d487fbb3b4200971680e9aaabfb77",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.jhepr.2026.102022"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2721|Liver Disease and Transplantation",
      "subfield": "general"
    }
  ],
  "title": "Hepatic encephalopathy in chronic liver disease: Emerging insights from the gut microbiome",
  "title_text": "Hepatic encephalopathy in chronic liver disease: Emerging insights from the gut microbiome",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T14:20:18Z",
  "url": "https://research.draconitic.com/paper/c4re1dfmm95rc",
  "venue": "JHEP Reports",
  "versions": []
}