{
  "abstract": "Omnipresent in biology, fibrous networks like collagen possess unique properties: dynamic network via crosslinking and degradation. This intrinsic adaptivity plays a critical role in regulating cell behavior via cell-matrix interactions. Built from biological building blocks, however, these networks are challenging to manipulate or even control. Here, we introduce dynamic network regulation via photochemical control in a synthetic and fibrous highly biomimetic hydrogel. As a proof-of-concept, we demonstrate that the dynamic control over the mechanical properties of this adaptive in vitro model can be used to modulate cell spreading and mechanotransduction in three-dimensional (3D) mesenchymal stromal cell cultures. Our approach not only opens the door to on-demand mechanically adaptive gels with unprecedented control, but simultaneously offers easy processibility and cell extraction of the used synthetic gel.",
  "abstract_shown": true,
  "affiliations": [
    "Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.",
    "MERLN Institute for Technology-Inspired Regenerative Medicine, Department of Complex Tissue Regeneration, Maastricht University, The Netherlands.",
    "Molecular imaging and Photonics, department of chemistry, KU Leuven, Flanders, Belgium.",
    "Key laboratory of Molecular Biophysics of Hebei Province, institute of Biophysics,School of health Sciences and Biomedical engineering, Hebei University of technology, Tianjin 300401, P.R. China.",
    "Radboud University Medical Center, Department of Dentistry - Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Wen Chen",
      "orcid": "0000-0001-7017-6990"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhengdong Gao",
      "orcid": "0009-0004-9901-4097"
    },
    {
      "affs": [
        1
      ],
      "name": "Hongjuan Weng"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Hongbo Yuan",
      "orcid": "0000-0002-4250-195X"
    },
    {
      "affs": [
        0
      ],
      "name": "Roy van Alst"
    },
    {
      "affs": [
        4
      ],
      "name": "Rong Wang",
      "orcid": "0000-0002-6623-8439"
    },
    {
      "affs": [
        0
      ],
      "name": "Jyoti Kumari",
      "orcid": "0000-0003-4752-4533"
    },
    {
      "affs": [
        1
      ],
      "name": "Lorenzo Moroni",
      "orcid": "0000-0003-1298-6025"
    },
    {
      "affs": [
        0
      ],
      "name": "Paul H. J. Kouwer",
      "orcid": "0000-0002-2760-191X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c53006zd9rzyy.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aec7416",
  "fulltext_url": "https://europepmc.org/articles/PMC13685919",
  "id": "c53006zd9rzyy",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aec7416",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Hydrogels: synthesis, properties, applications"
    ]
  ],
  "openalex": "W7223146627",
  "pdf_url": "https://europepmc.org/articles/PMC13685919?pdf=render",
  "pmcid": "PMC13685919",
  "pmid": "42905813",
  "published": "2026-10-21",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/c53006zd9rzyy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aec7416",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aec7416"
    },
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42905813",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905813"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Hydrogels: synthesis, properties, applications",
      "subfield": "general"
    }
  ],
  "title": "In situ processing of fibrous hydrogels by photochemistry for adaptive cellular microenvironments",
  "title_text": "In situ processing of fibrous hydrogels by photochemistry for adaptive cellular microenvironments",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/c53006zd9rzyy",
  "venue": "Science Advances",
  "versions": []
}