{
  "abstract": "The growing brain faces the challenge to establish neural stem cell (NSC) populations that accomplish both stable NSC maintenance and dynamic generation of progenitors. Lineage-specific scRNA-seq and time series transcriptome analyses upon overexpression of Notch signaling components in the larval zebrafish brain reveal differential contributions of Notch signaling and Notch-independent Her6, a HES1 homolog, to NSC regulation. Notch signaling and Her6 distinctly regulate cell cycle genes to control G0/G1 or G2 exit and promote quiescence. Her6 and Notch activity combined differentially control delta, jagged, lfng and notch3 expression to potentially shift Notch signaling from Delta-driven lateral inhibition to Jagged-Notch3-mediated lateral induction. We propose that Her6 integrates cell-autonomous lineage-based information and lateral induction-mediated non-autonomous self-organization of neural proliferation zones. Her6-dependent lateral induction maintains persistent NSC patches in ventricular compartments with ongoing neurogenesis, and establishes coherent populations of long-term NSCs in active proliferation zones.",
  "abstract_shown": true,
  "affiliations": [
    "Faculty of Biology, University of Freiburg, Freiburg, Germany"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "J. Rothenpieler"
    },
    {
      "name": "R. Veit"
    },
    {
      "name": "D. Stefanovska"
    },
    {
      "name": "J. Schwab"
    },
    {
      "name": "C. E. Sigloch"
    },
    {
      "name": "D. Gruen"
    },
    {
      "affs": [
        0
      ],
      "name": "W. Driever"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c53sztxjv3c4q.bib",
  "cited_by": 1,
  "doi": "10.64898/2026.09.16.752018",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.16.752018v1.full",
  "id": "c53sztxjv3c4q",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.16.752018v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "developmental biology"
    ],
    [
      "openalex",
      "2806|Neurogenesis and neuroplasticity mechanisms"
    ]
  ],
  "openalex": "W7213537681",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.16.752018v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c53sztxjv3c4q.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:04Z",
      "native_id": "10.64898/2026.09.16.752018",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.16.752018v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:developmental biology",
      "subfield": "developmental-biology"
    }
  ],
  "title": "Notch-independent Her6 contributes to control of neural stem cell maintenance by shifting Notch signaling from lateral inhibition towards lateral induction mode",
  "title_text": "Notch-independent Her6 contributes to control of neural stem cell maintenance by shifting Notch signaling from lateral inhibition towards lateral induction mode",
  "type": "preprint",
  "updated_at": "2026-11-01T00:21:13Z",
  "url": "https://research.draconitic.com/paper/c53sztxjv3c4q",
  "venue": "bioRxiv",
  "versions": []
}