{
  "abstract": "BACKGROUND: Few epidemiological studies have investigated the association between changes in serum N-terminal pro B-type natriuretic peptide (NT-proBNP) and mortality in the general Asian population. METHODS AND RESULTS: We followed 2,703 community-dwelling Japanese residents aged ≥40 years who had serum NT-proBNP concentrations measured in both 2002-2003 and 2007-2008 over a median period of 10.3 years. Changes in NT-proBNP were categorized as decreasing (change ≤-25%), no change (-25%<change<+25%), or increasing (change ≥+25%). Mortality hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. During the follow-up period, 497 deaths occurred (108 cardiovascular, 389 non-cardiovascular). Compared with the no-change group, multivariable-adjusted HRs in the increasing group were 1.73 (95% CI 1.37-2.17), 1.76 (95% CI 1.08-2.87), and 1.71 (95% CI 1.32-2.22) for all-cause, cardiovascular, and non-cardiovascular mortality, respectively. Subgroup analyses by baseline serum NT-proBNP concentration (2002-2003) showed consistent associations with all-cause mortality in both lower (<125 pg/mL) and higher (≥125 pg/mL) NT-proBNP groups, with a tendency towards stronger associations in the higher NT-proBNP group. CONCLUSIONS: Changes in serum NT-proBNP concentrations may indicate mortality risk in a community-dwelling Asian population.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Asahi Kato"
    },
    {
      "name": "Emi Oishi"
    },
    {
      "name": "Akihiro Maezono"
    },
    {
      "name": "Satoko Sakata"
    },
    {
      "name": "Yoshihiko Furuta"
    },
    {
      "name": "Mao Shibata"
    },
    {
      "name": "Jun Hata"
    },
    {
      "name": "Tetsuro Ago"
    },
    {
      "name": "Kohtaro Abe"
    },
    {
      "name": "Toshiharu Ninomiya"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c595fjftjzyzd.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-25-1168",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1168/_article",
  "id": "c595fjftjzyzd",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1168/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2705|Heart Failure Treatment and Management"
    ]
  ],
  "openalex": "W7204864506",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-25-1168/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c595fjftjzyzd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-25-1168",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/10/90_CJ-25-1168/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Heart Failure Treatment and Management",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Association Between Changes in Serum N-Terminal Pro B-Type Natriuretic Peptide Levels and All-Cause and Cause-Specific Mortality ― The Hisayama Study ―",
  "title_text": "Association Between Changes in Serum N-Terminal Pro B-Type Natriuretic Peptide Levels and All-Cause and Cause-Specific Mortality ― The Hisayama Study ―",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/c595fjftjzyzd",
  "venue": "Circulation Journal",
  "versions": []
}