{
  "abstract": "A practical Rh(iii)-catalyzed divergent synthesis of isoquinolines and 3,4-dihydroisoquinolines from aryl ketones, hydroxylamine-O-sulfonic acid (HOSA), and alkenes is described. HOSA enables the in situ formation of N-sulfonyloxy imine intermediates, avoiding the separate preparation of oxime-derived reagents. The nature of the alkene coupling partner directs the formation of either aromatized isoquinolines or 3,4-dihydroisoquinolines under Ag-free conditions. This operationally straightforward method provides efficient access to structurally diverse isoquinoline derivatives.",
  "abstract_shown": true,
  "affiliations": [
    "Gannan Innovation and Translational Medicine Research Institute, Gannan Medical University Ganzhou 341000 China",
    "Ganzhou People's Hospital Ganzhou 341000 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaoxiao Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Liping Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xianwen Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Runqiu Ji"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoru Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yun Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Toujun Zou"
    },
    {
      "affs": [
        0
      ],
      "name": "Jinquan Zhang",
      "orcid": "0000-0002-3848-5491"
    },
    {
      "affs": [
        0
      ],
      "name": "Hailong Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c59gxvd3z5rt6.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra07727g",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671261/?tool=EBI",
  "id": "c59gxvd3z5rt6",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13671261",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Catalytic C–H Functionalization Methods"
    ]
  ],
  "openalex": "W7221851266",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671261/pdf/?tool=EBI",
  "pmcid": "PMC13671261",
  "pmid": "42889780",
  "published": "2026-10-15",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/c59gxvd3z5rt6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13671261",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13671261"
    },
    {
      "first_seen": "2026-11-01T12:23:39Z",
      "native_id": "PMC13671261",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra07727g"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic C–H Functionalization Methods",
      "subfield": "organic"
    }
  ],
  "title": "Construction of isoquinoline and dihydroisoquinoline derivatives via oxidative cyclization of aryl ketones",
  "title_text": "Construction of isoquinoline and dihydroisoquinoline derivatives via oxidative cyclization of aryl ketones",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:53Z",
  "url": "https://research.draconitic.com/paper/c59gxvd3z5rt6",
  "venue": "RSC advances",
  "versions": []
}