{
  "abstract": "Background: Hypertension (HTN) constitutes a major and growing public health challenge in South Africa, a setting where HIV prevalence also remains high. Despite this dual burden, longitudinal evidence describing how individuals move through the HTN care cascade particularly comparing people living with HIV (PLHIV) and people not living with HIV (PNLHIV) remains limited. Understanding patterns of progression and regression across the cascade is essential to inform health system strategies for integrated chronic disease management. Methods and findings: We conducted a longitudinal secondary analysis using data collected from the iHEART-SA trial, implemented across nine public primary healthcare clinics in Johannesburg between August 2022 and May 2024, with follow-up through May 2025. Adults (≥18 years) receiving chronic care, with a known HIV status and a completed medical file review were included. Progression and regression were assessed across the HTN care cascade. Conclusions: PLHIV had lower HTN diagnosis and higher regression, including treatment discontinuation and loss of BP control, underscoring persistent gaps in longitudinal HTN management within HIV programmes and the need for integrated and targeted chronic care models that ensure treatment continuity and sustained control. Why was this study done?: What did the researchers do and find?: What do these findings mean?:",
  "abstract_shown": true,
  "affiliations": [
    "Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa",
    "Health Sciences Research Office (HSRO), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa",
    "Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America",
    "MRC/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa",
    "Institute for Collaboration on Health, Intervention and Policy, University of Connecticut, Storrs, Connecticut, United States of America",
    "Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, United States of America"
  ],
  "article_type": "Research Article",
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  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Siphamandla Bonga Gumede"
    },
    {
      "affs": [
        1
      ],
      "name": "Jennifer Manne-Goehler"
    },
    {
      "affs": [
        2
      ],
      "name": "Elizabeth Kelechi Oladimeji"
    },
    {
      "affs": [
        3
      ],
      "name": "Nicola Bulled"
    },
    {
      "affs": [
        4
      ],
      "name": "Alana T. Brennan"
    },
    {
      "affs": [
        5
      ],
      "name": "Samanta Tresha Lalla-Edward"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c5a4xe099kqvz.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pmed.1004957",
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  "id": "c5a4xe099kqvz",
  "issns": [
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  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
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      "openalex",
      "2705|Blood Pressure and Hypertension Studies"
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      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
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      "/Medicine and health sciences/Diagnostic medicine/HIV diagnosis and management"
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      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV"
    ],
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      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV"
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      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Cardiovascular therapy/Antihypertensive drug therapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmacology/Drugs/Antihypertensives"
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      "/Medicine and health sciences/Vascular medicine/Blood pressure/Hypertension"
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  "pdf_url": "https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004957&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/c5a4xe099kqvz.ris",
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  "subjects": [
    {
      "field": "biology",
      "origin": "plos:microbiology",
      "subfield": "microbiology"
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      "origin": "plos:pharmacology",
      "subfield": "pharmacology-toxicology"
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  "title": "The longitudinal care cascade for hypertension in people with and without HIV in South Africa: A clinic-based observational study",
  "title_text": "The longitudinal care cascade for hypertension in people with and without HIV in South Africa: A clinic-based observational study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/c5a4xe099kqvz",
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