{
  "abstract": "The senescence of leptin receptor-positive (LepR⁺) cells in bone marrow contributes to the development of the aged bone marrow microenvironment, and rescuing LepR⁺ cell senescence holds promise for alleviating age-related osteoporosis. This study reveals that senescent LepR⁺ cells establish a pro-senescent vicious cycle driven by decreased NO, reduced Mg²⁺, and continuously accumulated reactive oxygen species (ROS). To break this cycle, we constructed an aged microenvironment-triggered nanoreactor capable of releasing NO/Mg²⁺ and scavenging ROS to reverse cellular senescence. In this system, the nanoreactor (LPM) was fabricated via a thin-film hydration method, in which L-arginine was loaded into methoxy poly(ethylene glycol)-block-poly(propylene sulfide) (mPEG-b-PPS) and stabilized by Mg²⁺-mediated crosslinking. Coating LPM with senescent LepR⁺ cell membranes generated CLPM, which exhibited superior targeting to LepR⁺ cells, efficient NO/Mg²⁺ release, and potent ROS scavenging activity. CLPM treatment effectively rejuvenated senescent LepR⁺ cells, as evidenced by reduced senescence phenotypes and enhanced bone marrow regeneration. RNA sequencing further confirmed that CLPM disrupted the vicious cycle in senescent LepR⁺ cells and remodeled the aged bone marrow. Collectively, our findings suggest that the CLPM nanoreactor offers a promising approach for rejuvenation of the aging skeletal system.",
  "abstract_shown": true,
  "affiliations": [
    "Orthopedic Institute (Wuxi Key Laboratory of Orthopaedics & Wuxi Key Laboratory of Sports Medicine), Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214062, PR China.",
    "Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215000, PR China.",
    "Department of Orthopedic Trauma, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214062, PR China.",
    "Minimally Invasive Orthopedic Institute of Soochow University, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214062, PR China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Ke Li"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Zeqing Li"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Yuan Xue"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Hao Liu"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Jiangrong Guo"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Xuemei Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Bin Li"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Yongjun Rui"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c5eb21p3j2fa3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103751",
  "fulltext_url": "https://europepmc.org/articles/PMC13694972",
  "id": "c5eb21p3j2fa3",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927243",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Mesenchymal stem cell research"
    ]
  ],
  "openalex": "W7221538626",
  "pdf_url": "https://europepmc.org/articles/PMC13694972?pdf=render",
  "pmcid": "PMC13694972",
  "pmid": "42927243",
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c5eb21p3j2fa3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927243",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927243"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Mesenchymal stem cell research",
      "subfield": "human-genetics"
    }
  ],
  "title": "Aged microenvironment-triggered nanoreactors rejuvenate senescent LepR⁺ cells to remodel aged bone marrow.",
  "title_text": "Aged microenvironment-triggered nanoreactors rejuvenate senescent LepR⁺ cells to remodel aged bone marrow.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/c5eb21p3j2fa3",
  "venue": "Materials today. Bio",
  "versions": []
}