{
  "abstract": "Real-world disparities in access to PSMA-targeted theranostics are poorly characterized. We compared waiting times for PSMA PET/CT and 177Lu-PSMA therapy between centers in Brazil and Europe. Methods: This retrospective multicenter study included 91 patients (50 from Brazil, 41 from Europe) treated with 177Lu-PSMA. Outcomes were days from request to PSMA PET/CT completion (diagnostic access) and days from request to first therapy dose (therapeutic access). Groups were compared using the Mann–Whitney U test. Results: Diagnostic access was similar between Brazil (median, 17.5 d; interquartile range [IQR], 9–34 d) and Europe (median, 19 d; IQR, 14–23 d; P = 0.39). Therapeutic access was significantly delayed in Brazil (median, 59 d; IQR, 54.5–91) compared with Europe (median, 21 d; IQR, 17–31 d; P < 0.01), representing a 2.8-fold longer wait. Conclusion: Despite comparable access to PSMA PET/CT, initiation of 177Lu-PSMA therapy is nearly 3 times slower in Brazil than in Europe. Closing the therapeutic access gap requires targeted investments in radiopharmaceutical supply chains and regulatory efficiency.",
  "abstract_shown": true,
  "affiliations": [
    "Instituto Teranóstico Brasil, Curitiba, Brazil",
    "IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy",
    "Department of Nuclear Medicine, West German Cancer Center, DKTK and NCT Site, University Hospital Essen, Essen, Germany",
    "Department of Nuclear Medicine, IMEB–Institute of Nuclear Medicine of Brasília, Brasília, Brazil",
    "Instituto do Cancer e Transplante, Curitiba, Brazil",
    "CIONC, Curitiba, Brazil; and",
    "Division of Human Health, International Atomic Energy Agency, Vienna, Austria"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Juliano J. Cerci"
    },
    {
      "affs": [
        1
      ],
      "name": "Stefano Fanti"
    },
    {
      "affs": [
        2
      ],
      "name": "Ken Herrmann"
    },
    {
      "affs": [
        0
      ],
      "name": "Denise Ferreira Rodrigues"
    },
    {
      "affs": [
        0
      ],
      "name": "Pedro Henrique Furst Leite"
    },
    {
      "affs": [
        0
      ],
      "name": "Margaret Masukawa"
    },
    {
      "affs": [
        3
      ],
      "name": "Marcelo Moreira da Silva"
    },
    {
      "affs": [
        2
      ],
      "name": "Wolfgang P. Fendler"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Adriano Goncalves e Silva"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Elise Nara Sanfelice"
    },
    {
      "affs": [
        2
      ],
      "name": "Walter Ayelet"
    },
    {
      "affs": [
        1
      ],
      "name": "Fabio Ghetti"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrea Bascioni"
    },
    {
      "affs": [
        6
      ],
      "name": "Enrique E. Estrado Lobato"
    },
    {
      "affs": [
        6
      ],
      "name": "Diana Paez"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c5nq38g8pzpfq.bib",
  "cited_by": 0,
  "doi": "10.2967/jnumed.126.273029",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724724/",
  "id": "c5nq38g8pzpfq",
  "issns": [
    "0161-5505",
    "1535-5667"
  ],
  "landing_url": "https://doi.org/10.2967/jnumed.126.273029",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Communication"
    ],
    [
      "openalex",
      "2741|Radiopharmaceutical Chemistry and Applications"
    ]
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  "openalex": "W7203822680",
  "pdf_url": "https://jnm.snmjournals.org/content/jnumed/early/2026/08/20/jnumed.126.273029.full.pdf",
  "pmcid": "PMC13724724",
  "pmid": "42624649",
  "published": "2026-11-03",
  "publisher": "Society of Nuclear Medicine and Molecular Imaging",
  "ris": "https://research.draconitic.com/paper/c5nq38g8pzpfq.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:15Z",
      "native_id": "PMC13724724",
      "source": "pmc",
      "url": "https://doi.org/10.2967/jnumed.126.273029"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Radiopharmaceutical Chemistry and Applications",
      "subfield": "imaging"
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  ],
  "title": "The Global Theranostics Access Gap: Real-World Disparities in PSMA PET/CT and 177Lu-PSMA Therapy Between Centers in Brazil and Europe",
  "title_text": "The Global Theranostics Access Gap: Real-World Disparities in PSMA PET/CT and 177Lu-PSMA Therapy Between Centers in Brazil and Europe",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:08Z",
  "url": "https://research.draconitic.com/paper/c5nq38g8pzpfq",
  "venue": "Journal of Nuclear Medicine",
  "versions": []
}