{
  "abstract": "Background: Prospective comparative evidence for topical treatment of Zoon’s balanitis is limited. We evaluated early clinical changes during two topical regimens and explored recorded long-term outcomes. Methods: In this single-centre, prospective, open-label, non-randomised study, 37 men with histopathologically confirmed Zoon’s balanitis were allocated by alternation to fluticasone propionate 0.05% (n = 18) or fusidic acid 2% (n = 19) for four weeks. Early assessments used a four-point study Investigator’s Global Assessment (IGA) and symptom visual analogue scales. Additional exploratory comparisons included IGA 0 at week 4. A separate categorical assessment was undertaken in 2026. The study was not registered in a public clinical-trial registry. Results: Mean IGA decreased from 2.17 to 0.67 with fluticasone and from 2.26 to 0.89 with fusidic acid between baseline and week 4. Complete clearance occurred in 8/18 (44.4%) and 6/19 (31.6%) participants, respectively; the absolute difference was 12.9 percentage points (95% confidence interval, −17.1 to 40.1; Fisher’s exact p = 0.50768). Among participants assessable in 2026, recorded remission occurred in 12/16 (75.0%) and 3/15 (20.0%), respectively (unadjusted odds ratio, 12.00; approximate 95% confidence interval, 2.20–65.52; p = 0.00385). These data did not establish uninterrupted or treatment-free remission; missing-outcome sensitivity analyses limited the robustness of the association. Conclusions: Clinical severity improved during both regimens, but comparative equivalence was not established. The association between initial fluticasone allocation and recorded remission in 2026 is hypothesis-generating and requires confirmation in a registered, adequately powered controlled study with standardised long-term assessment.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, Venerology and Allergology, Medical University of Gdańsk, Mariana Smoluchowskiego 17, 80-214 Gdańsk, Poland",
    "Department of Urology, Medical University of Gdańsk, Mariana Smoluchowskiego 17, 80-214 Gdańsk, Poland"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Katarzyna Czajkowska",
      "orcid": "0000-0003-3296-3453"
    },
    {
      "affs": [
        1
      ],
      "name": "Mateusz Czajkowski",
      "orcid": "0000-0003-2017-5417"
    },
    {
      "affs": [
        0
      ],
      "name": "Roman Janusz Nowicki",
      "orcid": "0000-0003-4768-1387"
    },
    {
      "affs": [
        1
      ],
      "name": "Marcin Matuszewski"
    },
    {
      "affs": [
        0
      ],
      "name": "Małgorzata Sokołowska-Wojdyło",
      "orcid": "0000-0002-7626-3689"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c5xjk2jsnqqmy.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218515",
  "fulltext_url": null,
  "id": "c5xjk2jsnqqmy",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8515",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-02",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/c5xjk2jsnqqmy.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:42Z",
      "native_id": "10.3390/jcm15218515",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8515"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Topical Fluticasone Propionate Versus Fusidic Acid for Zoon’s Balanitis in Men: A Prospective, Open-Label, Non-Randomised Comparative Study with an Exploratory Long-Term Assessment",
  "title_text": "Topical Fluticasone Propionate Versus Fusidic Acid for Zoon’s Balanitis in Men: A Prospective, Open-Label, Non-Randomised Comparative Study with an Exploratory Long-Term Assessment",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/c5xjk2jsnqqmy",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}