{
  "abstract": "Structural studies of diverse viral RNA-dependent RNA polymerases reveal that the broad-spectrum antiviral Suramin binds distinct sites while repeatedly exploiting conserved RNA-interacting and electrostatic features. This Pearl highlights common vulnerabilities within viral RNA polymerases and discusses how structural studies provide a framework for future antiviral design.",
  "abstract_shown": true,
  "affiliations": [
    "Section of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, Minnesota, United States of America",
    "Department of Chemistry, Gustavus Adolphus College, St Peter, Minnesota, United States of America",
    "Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America"
  ],
  "article_type": "Pearls",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arwen Baer"
    },
    {
      "affs": [
        1
      ],
      "name": "Ge Yang"
    },
    {
      "affs": [
        2
      ],
      "name": "Fan Bu"
    },
    {
      "name": "Bin Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c5z9r3qhwajxd.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.ppat.1014766",
  "fulltext_url": "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014766",
  "id": "c5z9r3qhwajxd",
  "issns": [
    "1553-7374"
  ],
  "landing_url": "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014766",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1315|Enzyme Structure and Function"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/DNA-binding proteins/Polymerases"
    ],
    [
      "plos",
      "/Biology and life sciences/Immunology/Vaccination and immunization/Antiviral therapy"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Coronaviruses/SARS coronavirus/SARS CoV 2"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Hemorrhagic fever viruses/Ebola virus"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Microbial control/Antimicrobials/Antivirals"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Virology/Antivirals"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Virology/Viral replication"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Virology/Viral transmission and infection/Viral entry"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Hemorrhagic fever viruses/Ebola virus"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/RNA viruses/Coronaviruses/SARS coronavirus/SARS CoV 2"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/RNA viruses/Filoviruses/Ebola virus"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Coronaviruses/SARS coronavirus/SARS CoV 2"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Viruses/Viral pathogens/Hemorrhagic fever viruses/Ebola virus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Vaccination and immunization/Antiviral therapy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Coronaviruses/SARS coronavirus/SARS CoV 2"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Viral pathogens/Hemorrhagic fever viruses/Ebola virus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmacology/Drugs/Antimicrobials/Antivirals"
    ],
    [
      "plos",
      "/Medicine and health sciences/Public and occupational health/Preventive medicine/Vaccination and immunization/Antiviral therapy"
    ],
    [
      "plos",
      "/Physical sciences/Physics/Electricity/Electrostatics"
    ]
  ],
  "openalex": "W7225420587",
  "pdf_url": "https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1014766&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/c5z9r3qhwajxd.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:24Z",
      "native_id": "10.1371/journal.ppat.1014766",
      "source": "plos",
      "url": "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014766"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Suramin inspires next-generation broad-spectrum antiviral design targeting RdRps",
  "title_text": "Suramin inspires next-generation broad-spectrum antiviral design targeting RdRps",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:48Z",
  "url": "https://research.draconitic.com/paper/c5z9r3qhwajxd",
  "venue": "PLOS Pathogens",
  "versions": []
}