{
  "abstract": "Background: Suspected invasive pulmonary aspergillosis (IPA) is increasingly treated in intensive care, including in patients without classical immunosuppression. Whether current research definitions (European Organization for Research and Treatment of Cancer [EORTC]/Mycoses Study Group Education and Research Consortium (MSGERC), Invasive Fungal Diseases in Adult Patients in ICU [FUNDICU]) classify treated cases and predict mortality is unclear. Methods: We retrospectively included adults in 48 French intensive care units who received systemic antifungal therapy for suspected IPA (January 2022 to July 2024). Patients were categorized as having modified EORTC/MSGERC probable IPA, FUNDICU probable IPA, or unclassified. Ninety-day mortality was analyzed using multivariable Cox regression; heterogeneity was explored with unsupervised clustering. Results: = .24). In adjusted analyses, IPA categorization was not associated with mortality (FUNDICU vs EORTC: adjusted hazard ratio [aHR] = 0.86, 95% CI .62-1.20; unclassified vs EORTC: aHR = 0.89, .62-1.30). Age (aHR 1.03/year, 1.02-1.05), Sequential Organ Failure Assessment (1.06/point, 1.03-1.10), and frailty (1.17/point, 1.07-1.30) independently predicted 90-day mortality. Exploratory clustering identified 6 phenotypes with 90-day mortality ranging from 40% to 80%. Conclusions: Nearly 1 in 5 intensive care patients treated for suspected IPA were not classifiable by EORTC/MSGERC or FUNDICU definitions. Mortality was more strongly associated with age, frailty, and acute severity than with classification category, supporting ICU-focused diagnostic frameworks and risk stratification; these associations should be read in light of the treatment-based design and do not establish that the definitions lack diagnostic value.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 59,
  "authors": [
    {
      "name": "Antoine Villa"
    },
    {
      "name": "Benoit Painvin"
    },
    {
      "name": "Antoine Hérault"
    },
    {
      "name": "Pierre-Marie Bourgeois"
    },
    {
      "name": "Bastien Peiffer"
    },
    {
      "name": "Sibylle Cunat"
    },
    {
      "name": "Fanny Vincent"
    },
    {
      "name": "Luc Juban"
    },
    {
      "name": "Luc Desmedt"
    },
    {
      "name": "Marine de Bony de Lavergne"
    },
    {
      "name": "Marin Caumartin"
    },
    {
      "name": "Rania Bounab"
    },
    {
      "name": "Loïc Prez"
    },
    {
      "name": "Julien Dessajan"
    },
    {
      "name": "François Dhelft"
    },
    {
      "name": "Jérémie Mallet"
    },
    {
      "name": "Marc Pineton de Chambrun"
    },
    {
      "name": "Grégoire Fourcade"
    },
    {
      "name": "Cédric Darreau"
    },
    {
      "name": "Donatien de Marignan"
    },
    {
      "name": "Guillaume Louis"
    },
    {
      "name": "Florent Wallet"
    },
    {
      "name": "Maxime Desgrouas"
    },
    {
      "name": "Kévin Vanneck Kamdem"
    },
    {
      "name": "Hamza Chraibi"
    },
    {
      "name": "Florian Reizine"
    },
    {
      "name": "Tomas Urbina"
    },
    {
      "name": "Françoise Botterel"
    },
    {
      "name": "Fanny Lanternier"
    },
    {
      "name": "Laurence Millon"
    },
    {
      "name": "Saad Nseir"
    },
    {
      "name": "Nicolas de Prost"
    },
    {
      "name": "Jonathan Chelly"
    },
    {
      "name": "Marc Gainnier"
    },
    {
      "name": "Octave Cannac"
    },
    {
      "name": "Martin Cour"
    },
    {
      "name": "Emmanuelle Guérin"
    },
    {
      "name": "Sébastien Jochmans"
    },
    {
      "name": "Loïc Le Guennec"
    },
    {
      "name": "Damien Contou"
    },
    {
      "name": "Adrien Pons"
    },
    {
      "name": "Jean-Pierre Quenot"
    },
    {
      "name": "Fabrice Uhel"
    },
    {
      "name": "Asaël Berger"
    },
    {
      "name": "Maxens Decavele"
    },
    {
      "name": "Antoine Guillon"
    },
    {
      "name": "Pascal Beuret"
    },
    {
      "name": "Cindy Lage"
    },
    {
      "name": "Djamel Mokart"
    },
    {
      "name": "Octave Cannac"
    },
    {
      "name": "Victor Penaud"
    },
    {
      "name": "Antoine Lafarge"
    },
    {
      "name": "Julien Maizel"
    },
    {
      "name": "Rémy Nyga"
    },
    {
      "name": "Jean-Philippe Rigaud"
    },
    {
      "name": "Matthieu Turpin"
    },
    {
      "name": "Sophie Nagle"
    },
    {
      "name": "Pierre Bay"
    },
    {
      "name": "Keyvan Razazi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c68b8as1ypj93.bib",
  "cited_by": 0,
  "doi": "10.1093/ofid/ofag519",
  "fulltext_url": null,
  "id": "c68b8as1ypj93",
  "issns": [
    "2328-8957",
    "2328-8957"
  ],
  "landing_url": "https://hal.science/hal-05799891v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "2725|Antifungal resistance and susceptibility"
    ]
  ],
  "openalex": "W7203769604",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42682890",
  "published": "2026-09-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/c68b8as1ypj93.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "hal-05799891",
      "source": "hal",
      "url": "https://hal.science/hal-05799891v1"
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  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Unclassifiable Invasive Pulmonary Aspergillosis in the Intensive Care Unit: Insights From a Multicenter, Retrospective Cohort Study in France (2022–2024)",
  "title_text": "Unclassifiable Invasive Pulmonary Aspergillosis in the Intensive Care Unit: Insights From a Multicenter, Retrospective Cohort Study in France (2022–2024)",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/c68b8as1ypj93",
  "venue": "Open Forum Infectious Diseases",
  "versions": []
}