{
  "abstract": "Tissue engineering has advanced significantly, yet multicomponent hydrogels inspired by the compositional complexity of natural extracellular matrices (ECMs) are still underexplored. Most current hydrogels are based on single-component formulations, which can limit their biochemical and mechanical versatility. Developing synthetic multicomponent hydrogels remains challenging because it requires the controlled integration of multiple functional groups within a single material platform. Here, a biologically driven strategy is introduced by leveraging Acinetobacter baylyi ADP1, a bacterium that naturally produces extracellular polymeric substances (EPS) composed of a multicomponent matrix of polysaccharides and proteins. Through three-day cultivation and a simple extraction method, a hydrogel is obtained that can be methacrylated and photocrosslinked using red or blue light. This hydrogel is porous, cytocompatible, 3D-bioprintable, injectable, and undergoes rapid gelation for in situ crosslinking. This work highlights the potential of using bacterial-derived multicomponent hydrogels for biofabrication.",
  "abstract_shown": true,
  "affiliations": [
    "Tampere University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "S. Radmehr"
    },
    {
      "name": "P. C. Ingoni"
    },
    {
      "name": "A. Eftekhari"
    },
    {
      "name": "L. Ylä-Outinen"
    },
    {
      "name": "V. S. Parihar"
    },
    {
      "name": "M. Khavani"
    },
    {
      "name": "N. Perho"
    },
    {
      "name": "J. Morikka"
    },
    {
      "name": "D. Greco"
    },
    {
      "name": "T. Laaksonen"
    },
    {
      "name": "M. Kellomäki"
    },
    {
      "name": "H. Skottman"
    },
    {
      "affs": [
        0
      ],
      "name": "S. Santala"
    },
    {
      "affs": [
        0
      ],
      "name": "V. Santala"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c6aym0gr55d19.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.11.750904",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.11.750904v1.full",
  "id": "c6aym0gr55d19",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.11.750904v1",
  "language": null,
  "licence": "CC-BY-ND",
  "licence_label": "CC BY-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioengineering"
    ],
    [
      "openalex",
      "1313|Hydrogels: synthesis, properties, applications"
    ]
  ],
  "openalex": "W7213321199",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.11.750904v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c6aym0gr55d19.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:21Z",
      "native_id": "10.64898/2026.09.11.750904",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.11.750904v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioengineering",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "3D-Printable and Cytocompatible Hydrogel from Acinetobacter baylyi ADP1 Extracellular Matrix",
  "title_text": "3D-Printable and Cytocompatible Hydrogel from Acinetobacter baylyi ADP1 Extracellular Matrix",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:39Z",
  "url": "https://research.draconitic.com/paper/c6aym0gr55d19",
  "venue": "bioRxiv",
  "versions": []
}