{
  "abstract": "Background\n\nAcne-induced post-inflammatory hyperpigmentation (PIH) is driven by Cutibacterium acnes-mediated inflammation and dysregulated melanogenesis; however, effective treatments targeting both processes remain limited.Objective\n\nThis study aimed to evaluate the anti-bacterial, anti-inflammatory, and anti-melanogenic effects of a newly made 2-isopropyl-5-methylphenol-conjugated valine-tryptophan dipeptide (2IP5MP-VW).Methods\n\nIPMP-VW conjugates were synthesized and screened for antibacterial activity against C. acnes. The effects of 2IP5MP-VW on inflammation and melanogenesis were assessed using Raw 264.7 macrophages and Mel-ab cells, and ex-vivo human skin.Results\n\nAmong the synthesized candidates, 2IP5MP-VW showed the strongest antibacterial activity against C. acnes. 2IP5MP-VW suppressed lipopolysaccharide-induced nitric oxide (NO) production via downregulation of inducible NO synthase without cytotoxicity. It also reduced melanin content in both unstimulated and forskolin-stimulated melanocytes. In ex vivo human skin, 2IP5MP-VW showed a decreasing trend in ultraviolet B-induced melanin accumulation.Conclusion\n\n2IP5MP-VW exhibits multifunctional anti-bacterial, anti-inflammatory, and anti-melanogenic activities, suggesting its potential as a candidate for the management of acne-induced PIH.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.",
    "Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.",
    "Dermafirm Inc., Derma Science Lab, Ltd., Seoul, Korea.",
    "Department of Brain Sciences, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ysong@amc.seoul.kr.",
    "Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. cse@amc.seoul.kr."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mina Song",
      "orcid": "0009-0003-5200-9189"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeong Hyeon Lee",
      "orcid": "0000-0001-5160-1760"
    },
    {
      "affs": [
        1
      ],
      "name": "Si-Eun Park",
      "orcid": "0009-0000-7484-8395"
    },
    {
      "affs": [
        2
      ],
      "name": "Jung Im Lee",
      "orcid": "0009-0007-2297-0859"
    },
    {
      "affs": [
        3
      ],
      "name": "Youngsup Song",
      "orcid": "0000-0002-6268-5223"
    },
    {
      "affs": [
        4
      ],
      "name": "Sung Eun Chang",
      "orcid": "0000-0003-4225-0414"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c6m3m9q6gcnj5.bib",
  "cited_by": 0,
  "doi": "10.5021/ad.26.029",
  "fulltext_url": "https://europepmc.org/articles/PMC13655619",
  "id": "c6m3m9q6gcnj5",
  "issns": [
    "1013-9087",
    "2005-3894"
  ],
  "landing_url": "https://europepmc.org/article/MED/42845207",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|melanin and skin pigmentation"
    ]
  ],
  "openalex": "W7203905715",
  "pdf_url": "https://europepmc.org/articles/PMC13655619?pdf=render",
  "pmcid": "PMC13655619",
  "pmid": "42845207",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c6m3m9q6gcnj5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42845207",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42845207"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|melanin and skin pigmentation",
      "subfield": "cell-biology"
    }
  ],
  "title": "Antibacterial, Anti-Inflammatory and Anti-Melanogenic Effects of a Novel Peptide.",
  "title_text": "Antibacterial, Anti-Inflammatory and Anti-Melanogenic Effects of a Novel Peptide.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/c6m3m9q6gcnj5",
  "venue": "Annals of dermatology",
  "versions": []
}