{
  "abstract": "BACKGROUND AND PURPOSE: Management of head-and-neck cancer (HNC) requires a precise imaging pretreatment assessment. The complementarity of MRI and PET in a single examination permit a comprehensive multimodality tumor characterization with matching spatiotemporal data. We aimed to assess the performance of simultaneous [18F]FDG-PET/MR for TNM-staging of HNC. METHODS: Consecutive HNC patients who underwent [18F]FDG-PET/MR examination were included in this single-institution retrospective study. The protocol included simultaneous [18F]FDG-PET/MR acquisitions, first head-and-neck, then of the whole-body. We assessed T and N-staging on [18F]FDG-PET/MR based on the AJCC manual 7th-edition. Results from histopathology served as the reference standard. Sensitivity, specificity, positive and negative predictive values and accuracy were calculated. Detection rates of metastases and synchronous diseases were analyzed according to patients’ follow-up. RESULTS: We included 117 patients (62 men, 59.2±17.4) with 124 examinations: 77 (62%) initial stagings, 32 (26%) restagings and 15 (12%) therapeutic evaluations. Histopathological data of resected tumors was available in 69 cases. [18F]FDG-PET/MR accuracy for defining T-stage was 0.89 at initial staging, 0.83 at restaging and 1 at follow-up, resulting in an overall accuracy of 89%. Among the 59 patients with cervical-node resection, 51 (86%) were correctly staged by [18F]FDG-PET/MR. Its accuracy for lymph-node characterization was 0.86 at initial staging, 0.92 at restaging and 0.82 at follow-up. CONCLUSIONS: [18F]FDG-PET/MR has excellent diagnostic performances for both T and N-staging in HNC, showing a good accuracy whether it was at initial staging, restaging or during the follow-up.",
  "abstract_shown": true,
  "affiliations": [
    "From the Neuroradiology Department (N.P., M.S.-A.), Sorbonne University, Pitié Salpêtrière-Charles Foix Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France",
    "L’Institut national de la santé et de la recherche médicale (N.P.), CNRS UMR 7225, Sorbonne University, UMR S 1127, Institut du Cerveau et de la Moelle épinière, Paris, France",
    "Nuclear Medicine Department (S.B., G.B., A.K.), Assistance Publique-Hôpitaux de Paris, Sorbonne Université Pitié Salpêtrière Hospital, Paris, France",
    "Laboratoire d’Imagerie Biomédicale (S.B., A.G., A.K.), Sorbonne University, L’Institut national de la santé et de la recherche médicale, Paris, France",
    "Pathological anatomy and cytology laboratory (G.H.), Centre hospitalier métropole Savoie, Chambéry, France",
    "Maxillo-Facial Surgery Department (C.B.), Sorbonne University, Pitié Salpêtrière-Charles Foix Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France",
    "CIMI Sorbonne University UPMC UMRS CR7 (C.B.), L’Institut national de la santé et de la recherche médicale U1135, CNRS ERL, Paris, France."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Nadya Pyatigorskaya",
      "orcid": "0000-0002-2070-1299"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Sarah Boughdad"
    },
    {
      "affs": [
        2
      ],
      "name": "Geraldine Bera",
      "orcid": "0000-0002-6666-7372"
    },
    {
      "affs": [
        3
      ],
      "name": "Alain Giron",
      "orcid": "0000-0003-0888-6312"
    },
    {
      "affs": [
        4
      ],
      "name": "Geneviève Hervé"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Chloé Bertolus",
      "orcid": "0000-0002-4279-9805"
    },
    {
      "affs": [
        0
      ],
      "name": "Melika Sahli-Amor"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Aurelie Kas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c6y1hxcj9ragm.bib",
  "cited_by": 0,
  "doi": "10.3174/ajnr.a9377",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738318/",
  "id": "c6y1hxcj9ragm",
  "issns": [
    "0195-6108",
    "1936-959X"
  ],
  "landing_url": "https://doi.org/10.3174/ajnr.a9377",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical"
    ],
    [
      "heading",
      "Molecular Neuroimaging/Nuclear Medicine"
    ],
    [
      "openalex",
      "2741|Medical Imaging Techniques and Applications"
    ]
  ],
  "openalex": "W7155625627",
  "pdf_url": null,
  "pmcid": "PMC13738318",
  "pmid": "42034564",
  "published": "2026-11-06",
  "publisher": "American Society of Neuroradiology",
  "ris": "https://research.draconitic.com/paper/c6y1hxcj9ragm.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:19Z",
      "native_id": "PMC13738318",
      "source": "pmc",
      "url": "https://doi.org/10.3174/ajnr.a9377"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Medical Imaging Techniques and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "[18F] FDG-PET/MRI Performance in Head and Neck Cancers at Initial Staging, Restaging, and Follow-up",
  "title_text": "[18F] FDG-PET/MRI Performance in Head and Neck Cancers at Initial Staging, Restaging, and Follow-up",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:19Z",
  "url": "https://research.draconitic.com/paper/c6y1hxcj9ragm",
  "venue": "AJNR: American Journal of Neuroradiology",
  "versions": []
}