{
  "abstract": "Purpose: [68Ga]Ga-ATH001 is an Affibody molecule targeting PDGFRβ in development as a Positron Emission Tomography (PET) tracer for non-invasive imaging of active fibrosis. Here we present first-in-human [68Ga]Ga-ATH001 biodistribution and radiation dosimetry data.\n\nMethods: Radiation dosimetry of [68Ga]Ga-ATH001 was evaluated in healthy participants (n = 3) and participants with metabolic dysfunction-associated steatohepatitis (MASH) (n = 3). Each participant was intravenously administered ~ 2.5 MBq/kg [68Ga]Ga-ATH001 and imaged by whole-body PET for up to 3 h post-injection. Absorbed dose coefficients and effective doses according to ICRP 103 were calculated using IDAC DOSE 2.1.\n\nResults: The effective dose of [68Ga]Ga-ATH001 was 0.028 ± 0.002 mSv/MBq with kidneys as the dose-limiting organ. Administration of a target dose of 2 MBq/kg would result in a sex-averaged effective dose of 4.1 mSv. Subjects tolerated the tracer administration well.\n\nConclusion: [68Ga]Ga-ATH001 demonstrates a dosimetry and safety profile that supports further clinical development as a repeatable, non-invasive PET marker of active fibrosis in tissue.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00259-026-08167-9.",
  "abstract_shown": true,
  "affiliations": [
    "Molecular Imaging and Medical Physics, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden",
    "Takeda Development Center Americas, Inc, Cambridge, MA USA",
    "Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden",
    "Department of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden",
    "Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden",
    "Theranostics Trial Center, Karolinska Institutet, Stockholm, Sweden",
    "Antaros Tracer AB, Uppsala, Sweden",
    "Antaros Medical AB, Gothenburg, Sweden",
    "Department of Gastroenterology and Hepatology, Uppsala University Hospital, Uppsala, Sweden",
    "Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden",
    "Department of Medicinal Chemistry, Science for Life Laboratory, Uppsala University, Dag Hammarskjölds Väg 14 C, 3Tr SE-751 83, Uppsala, Sweden"
  ],
  "article_type": "brief report",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mark Lubberink"
    },
    {
      "affs": [
        1
      ],
      "name": "Talakad G. Lohith"
    },
    {
      "affs": [
        1
      ],
      "name": "Zoltan Derdak"
    },
    {
      "affs": [
        1
      ],
      "name": "Paul Wilkens"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Emilia Palmér"
    },
    {
      "affs": [
        3
      ],
      "name": "Alexandra Ramolli"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Mélodie Ferrat"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Thuy A. Tran"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Bogdan Mitran"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Ayman Abouyzayed"
    },
    {
      "affs": [
        7
      ],
      "name": "Lars Johansson"
    },
    {
      "affs": [
        1
      ],
      "name": "Haakan Wennbo"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Fredrik Rorsman"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Johan Vessby"
    },
    {
      "affs": [
        6,
        10
      ],
      "name": "Olof Eriksson",
      "orcid": "0000-0002-2515-8790"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c7030m7p333wk.bib",
  "cited_by": 0,
  "doi": "10.1007/s00259-026-08167-9",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13727816/",
  "id": "c7030m7p333wk",
  "issns": [
    "1619-7070",
    "1619-7089"
  ],
  "landing_url": "https://doi.org/10.1007/s00259-026-08167-9",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Short Communication"
    ],
    [
      "openalex",
      "2741|Radiopharmaceutical Chemistry and Applications"
    ]
  ],
  "openalex": "W7211954381",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00259-026-08167-9.pdf",
  "pmcid": "PMC13727816",
  "pmid": "42709070",
  "published": "2026-09-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c7030m7p333wk.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:23:37Z",
      "native_id": "PMC13727816",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00259-026-08167-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Radiopharmaceutical Chemistry and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "Biodistribution and radiation dosimetry of the PDGFRβ targeting PET tracer [68Ga]Ga-ATH001",
  "title_text": "Biodistribution and radiation dosimetry of the PDGFRβ targeting PET tracer [68Ga]Ga-ATH001",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:56Z",
  "url": "https://research.draconitic.com/paper/c7030m7p333wk",
  "venue": "European Journal of Nuclear Medicine and Molecular Imaging",
  "versions": []
}