{
  "abstract": "Impact of nutrition on systemic health is well-recognized but the specific sensors that couple western dietary lipid metabolites into the pathological triggers of chronic itch and inflammation remain elusive. Here, we identify a metabolic- to-sensory axis in which 9-keto-12,13-epoxy octadecenoic acid (EKODE), an endogenous dietary linoleic acid derivative acts as a potent ligand for the G protein-coupled receptor 35 (Gpr35) to drive chronic itch, inflammation, and heat hypersensitivity. We demonstrate that Gpr35 is selectively expresses in a distinct population of sensory neurons and genetic ablation of Gpr35 in sensory neurons attenuates EKODE and psoriasis-associated itch and inflammation. Furthermore, pharmacological inhibition of Gpr35 significantly attenuates itch in mouse models of psoriasis and atopic dermatitis. We show that Gpr35 signaling engages the itch-specific brain natriuretic peptide, defining a labeled-line pathway that is functionally distinct from classical nociceptive circuits. Collectively, our findings establish Gpr35 as a critical neuro-metabolic sensor in healthy and disease conditions.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "name": "Joshua J. Wheeler",
      "orcid": "0000-0002-1879-1627"
    },
    {
      "name": "Alla Lyfenko"
    },
    {
      "name": "Nesia A. Zurek",
      "orcid": "0009-0003-7939-2886"
    },
    {
      "name": "Keaton Song",
      "orcid": "0009-0009-9546-4273"
    },
    {
      "name": "Andy Wangzhou",
      "orcid": "0000-0001-5667-1223"
    },
    {
      "name": "Sruti Bontala"
    },
    {
      "name": "Ojasvi Deep"
    },
    {
      "name": "Jacob Casey"
    },
    {
      "name": "Ramsey Kubofcik",
      "orcid": "0009-0004-6494-3734"
    },
    {
      "name": "Daniel L. Schaffer"
    },
    {
      "name": "Hassan Melhem"
    },
    {
      "name": "Gregory S. Keyes"
    },
    {
      "name": "John M. Davis"
    },
    {
      "name": "Jan Hendrik Niess",
      "orcid": "0000-0001-6902-5650"
    },
    {
      "name": "Theodore J. Price",
      "orcid": "0000-0002-6971-6221"
    },
    {
      "name": "Christopher E. Ramsden"
    },
    {
      "name": "Brian S. Kim",
      "orcid": "0000-0002-8100-7161"
    },
    {
      "name": "Sascha R. A. Alles",
      "orcid": "0000-0001-8532-8950"
    },
    {
      "name": "Santosh K. Mishra",
      "orcid": "0000-0003-1149-3480"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c72yef6vq9338.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11087-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13720025",
  "id": "c72yef6vq9338",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11087-x",
  "language": "eng",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.nature.com/articles/s42003-026-11087-x.pdf",
  "pmcid": "PMC13720025",
  "pmid": "42957844",
  "published": "2026-10-29",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/c72yef6vq9338.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "10.1038/s42003-026-11087-x",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11087-x"
    },
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42957844",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957844"
    },
    {
      "first_seen": "2026-11-02T12:23:53Z",
      "native_id": "PMC13720025",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s42003-026-11087-x"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "Metabolic sensor Gpr35 links dietary lipids to itch mediating neural circuits",
  "title_text": "Metabolic sensor Gpr35 links dietary lipids to itch mediating neural circuits",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:00Z",
  "url": "https://research.draconitic.com/paper/c72yef6vq9338",
  "venue": "Communications Biology",
  "versions": []
}