{
  "abstract": "It has been known for more than half a century that enzymes can polymerize to either activate or repress their catalytic functions. Using cryo-EM, we serendipitously found that two commonly used enzymes in molecular microbiology research, alkaline phosphatase and proteinase K, can unexpectedly form filaments. While the physiological significance of fibrillation in alkaline phosphatase and proteinase K is unknown, the atomic models of these polymers show the ability of cryo-EM to discover and determine high resolution structures of macromolecular assemblies before they have been characterized or purified.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Ravi R Sonani"
    },
    {
      "name": "Iman Chouikha"
    },
    {
      "name": "Thijs Bodson"
    },
    {
      "name": "Silvia Hidalgo-Martinez"
    },
    {
      "name": "Filip J R Meysman"
    },
    {
      "name": "Han Remaut"
    },
    {
      "name": "Geneviève Ball"
    },
    {
      "name": "Edward H Egelman"
    },
    {
      "name": "Romé Voulhoux"
    },
    {
      "name": "Mike Sleutel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c76e3275gcd3e.bib",
  "cited_by": 0,
  "doi": "10.1128/spectrum.02439-26",
  "fulltext_url": null,
  "id": "c76e3275gcd3e",
  "issns": [
    "2165-0497"
  ],
  "landing_url": "https://hal.science/hal-05737098v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1315|Advanced Electron Microscopy Techniques and Applications"
    ]
  ],
  "openalex": "W7208811981",
  "pdf_url": "https://hal.science/hal-05737098/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-11",
  "publisher": "American Society for Microbiology",
  "ris": "https://research.draconitic.com/paper/c76e3275gcd3e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:27Z",
      "native_id": "hal-05737098",
      "source": "hal",
      "url": "https://hal.science/hal-05737098v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1315|Advanced Electron Microscopy Techniques and Applications",
      "subfield": "structural-biology"
    }
  ],
  "title": "Protein polymers proliferate: polymerization of phosphatases and proteases",
  "title_text": "Protein polymers proliferate: polymerization of phosphatases and proteases",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:27Z",
  "url": "https://research.draconitic.com/paper/c76e3275gcd3e",
  "venue": "Microbiology Spectrum",
  "versions": []
}