{
  "abstract": "Birch pollen-sensitized patients co-sensitized to Bet v 1 and Bet v 2 allergens present more frequent and severe respiratory or plant-related food allergy symptoms (PFASs). This study analyzed the relevance of Bet v 1 and profilin sensitization in the clinical phenotype of pollen-allergic patients in Belgium. Ten patients allergic to birch pollen (BPA), 31 to grass pollen (GPA) and 33 to both pollens (MPA), with rhino-conjunctivitis with/without asthma (ARRC), were evaluated by means of questionnaire, skin-prick tests and specific IgE assays. Half of GPA were co-sensitized to birch pollen, and no BPA were sensitized to profilin. The prevalence of asthma and pollen-related food allergy syndrome (PFAS) was higher in BPA than in MPA or GPA, with a higher severity of PFAS in asthmatic BPA. GPA with PFAS were more frequently sensitized to Bet v 1, with higher levels of rBet v 1-IgE. The prevalence of PFAS, together with the duration of rhinitis and PFAS tended to increase in profilin-polysensitized vs. mono- and un-sensitized GPA, regardless of Bet v 1-IgE and the severity of symptoms.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pulmonary Medicine, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium",
    "Allergy Center Saint-Luc, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium",
    "Lung, Nose and Skin Research Unit (LUNS), Institute of Experimental and Clinical Research (IREC), Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium",
    "Faculty of Medicine, Campus of Woluwé-Saint-Lambert, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium",
    "Dispens′s Soins, 6200 Châtelet, Belgium",
    "Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium",
    "Department of Otgorhinolaryngology, Hôpital Delta, 1160 Brussels, Belgium",
    "Department of Pulmonary Medicine, University Hospital Center UCL Namur, Godinne Site, 5530 Yvoir, Belgium",
    "Allergy Center Godinne, University Hospital Center UCL Namur, Godinne Site, 5330 Yvoir, Belgium",
    "Experimental and Clinical Research Institute (IREC), Center for Applied Molecular Technologies, Catholic University of Louvain (UCLouvain), 1200 Brussels, Belgium"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Françoise Pirson",
      "orcid": "0000-0002-5335-3702"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Esmeralda Fraille Lopez"
    },
    {
      "affs": [
        1,
        2,
        5,
        6
      ],
      "name": "Cloé Hupin"
    },
    {
      "affs": [
        2,
        7,
        8
      ],
      "name": "Carine Sohy",
      "orcid": "0000-0002-6287-3013"
    },
    {
      "affs": [
        1,
        9
      ],
      "name": "Bertrand Bearzatto",
      "orcid": "0000-0001-5193-6819"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Marylène Lecocq"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Charles Pilette",
      "orcid": "0000-0001-6685-0356"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c7jn9m2ngrngc.bib",
  "cited_by": 0,
  "doi": "10.3390/cells15201907",
  "fulltext_url": "https://europepmc.org/articles/PMC13703822",
  "id": "c7jn9m2ngrngc",
  "issns": [
    "2073-4409"
  ],
  "landing_url": "https://www.mdpi.com/2073-4409/15/20/1907",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2723|Allergic Rhinitis and Sensitization"
    ]
  ],
  "openalex": "W7223010292",
  "pdf_url": "https://europepmc.org/articles/PMC13703822?pdf=render",
  "pmcid": "PMC13703822",
  "pmid": "42929879",
  "published": "2026-10-20",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/c7jn9m2ngrngc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:02Z",
      "native_id": "10.3390/cells15201907",
      "source": "crossref",
      "url": "https://www.mdpi.com/2073-4409/15/20/1907"
    },
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929879",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929879"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2723|Allergic Rhinitis and Sensitization",
      "subfield": "immunology"
    }
  ],
  "title": "Bet v 1 Allergen Is the Main Driver of Disease in Patients with Pollen Allergy in Belgium",
  "title_text": "Bet v 1 Allergen Is the Main Driver of Disease in Patients with Pollen Allergy in Belgium",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/c7jn9m2ngrngc",
  "venue": "Cells",
  "versions": []
}