{
  "abstract": "Cellular senescence is a central hallmark of aging, yet its measurement in humans remains invasive, low-throughput and tissue-specific, precluding population-scale study. We developed Methylation-associated Gene Expression (MaGE) predictors: whole-blood DNA methylation proxies of p14ARF, p16INK4A and p21CIP1 expression, plus a composite score, providing the first scalable measure of senescence-marker expression. Deployed across Generation Scotland (n=18,859), MaGE yielded 45 Bonferroni-significant associations spanning 18 incident diseases and all-cause mortality. The two strongest associations recapitulated the established tissue specificity of p21CIP1 and p16INK4A activation, with MaGE-p21 associating with incident alcoholic liver disease and MaGE-p16 with pulmonary fibrosis. In a separate study, MaGE tracked disease severity and treatment response in Crohns disease. MaGE is a scalable, interpretable biomarker of senescence that enables its study at population scale and offers a route to patient stratification in senolytic trials.",
  "abstract_shown": true,
  "affiliations": [
    "Mayo Clinic, Rochester MN"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "D. J. Simpson"
    },
    {
      "name": "S. J. Crofts"
    },
    {
      "name": "C. Mavrommatis"
    },
    {
      "name": "T. A. White"
    },
    {
      "name": "Y. J. Suwanlikit"
    },
    {
      "name": "K. Loyva"
    },
    {
      "name": "W. A. Rocca"
    },
    {
      "name": "K. Kantarci"
    },
    {
      "name": "M. Mielke"
    },
    {
      "name": "A. Richmond"
    },
    {
      "name": "R. E. Marioni"
    },
    {
      "name": "K. Kirschner"
    },
    {
      "name": "N. K. LeBrasseur"
    },
    {
      "affs": [
        0
      ],
      "name": "T. Chandra"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c7s4a105703cs.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.29.26364335",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364335v1.full",
  "id": "c7s4a105703cs",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364335v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "epidemiology"
    ],
    [
      "openalex",
      "2737|Telomeres, Telomerase, and Senescence"
    ]
  ],
  "openalex": "W7215111784",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364335v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c7s4a105703cs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:51Z",
      "native_id": "10.64898/2026.09.29.26364335",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.29.26364335v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:epidemiology",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Methylation-associated Gene Expression (MaGE): a non-invasive, in vivo measure of cellular senescence.",
  "title_text": "Methylation-associated Gene Expression (MaGE): a non-invasive, in vivo measure of cellular senescence.",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:51Z",
  "url": "https://research.draconitic.com/paper/c7s4a105703cs",
  "venue": "medRxiv",
  "versions": []
}