{
  "abstract": "Objective: We aim to investigate the clinical, laboratory, and biological characteristics of patients with hypermucoviscous Klebsiella pneumoniae (hmKp) infections across various community settings to inform early screening of high-risk patients and improve treatment success rates.\n\nMethods: Patients were categorized into hmKp and non-hmKp groups. We analyzed the clinical presentation, laboratory findings, infection sites, and drug-sensitivity test results of the clinical isolates to identify mortality risk factors associated with hmKp infections.\n\nResults: The mortality rate for patients with multisite infection involving the lungs and bloodstream was as high as 76% in hmKp group, surpassing that in the non-hmKp group, although this difference was not statistically significant (p = 0.055). Invasive infections most frequently occurred concurrently with infections of the liver, lungs, and bloodstream. The resistance and mortality rates for hmKp infection were both 17%. Notably, nearly 18% of the patients had concurrent intracranial infections, which had the highest mortality risk of 100% for hmKp. Although both hmKp and non-hmKp strains were sensitive to most antibiotics, the non-hmKp strains exhibited higher antibiotic resistance. Multivariate regression analysis identified advanced age (OR: 1.04; 95% CI: 1.01-1.08; p = 0.024) and high SOFA (OR: 1.49; 95% CI: 1.21-1.83, p = 0.000) and APACHE II scores (OR: 1.10; 95% CI: 1.00-1.20, p = 0.049) as independent mortality risk factors for patients with hmKp.\n\nConclusions: HmKp infections at varied anatomical locations exhibit significant prognostic differences. Invasive infections pose a particularly high mortality risk. Timely treatment escalation may improve prognosis among older patients with high SOFA and APACHE II scores.",
  "abstract_shown": true,
  "affiliations": [
    "Intensive Care Unit Department, Zhongshan City People's Hospital, Guangdong Province, China",
    "Department of Respiratory Medicine, Zhongshan City People's Hospital, Guangdong Province, China",
    "Intensive Care Unit Department, Zhongshan Huangpu People's Hospital, Guangdong Province, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hongkui Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Li Lei"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenqing Lai"
    },
    {
      "affs": [
        2
      ],
      "name": "Qingbiao Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Miaolian Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c7sg1bzrmgxbv.bib",
  "cited_by": 0,
  "doi": "10.3855/jidc.22340",
  "fulltext_url": "https://www.jidc.org/index.php/journal/article/view/22340",
  "id": "c7sg1bzrmgxbv",
  "issns": [
    "1972-2680",
    "2036-6590"
  ],
  "landing_url": "https://doi.org/10.3855/jidc.22340",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QR1-502"
    ],
    [
      "lcc",
      "RC31-1245"
    ],
    [
      "openalex",
      "2726|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7225817956",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "The Journal of Infection in Developing Countries",
  "ris": "https://research.draconitic.com/paper/c7sg1bzrmgxbv.ris",
  "sources": [
    {
      "first_seen": "2026-11-12T14:35:09Z",
      "native_id": "0d9cf9570292493db739b2f4419dd2c6",
      "source": "doaj",
      "url": "https://doi.org/10.3855/jidc.22340"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2726|Antibiotic Resistance in Bacteria",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Clinical characteristics, infection sites, and mortality risk factors in community-acquired hypermucoviscous Klebsiella pneumoniae infections",
  "title_text": "Clinical characteristics, infection sites, and mortality risk factors in community-acquired hypermucoviscous Klebsiella pneumoniae infections",
  "type": "peer-reviewed",
  "updated_at": "2026-11-12T14:58:20Z",
  "url": "https://research.draconitic.com/paper/c7sg1bzrmgxbv",
  "venue": "Journal of Infection in Developing Countries",
  "versions": []
}