{
  "abstract": "The present study evaluated the applicability of time-domain NMR (TD-NMR) for detecting crystalline ibuprofen components in ibuprofen-loaded mesoporous silica.Ibuprofen-loaded mesoporous silica samples with different drug loadings were prepared, and the physical state of ibuprofen was characterized by nitrogen adsorption, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), 13 C solid-state NMR spectroscopy, and TD-NMR relaxation measurements.PXRD, DSC, and 13 C solid-state NMR spectroscopy did not clearly detect crystalline ibuprofen in samples with ibuprofen loadings of 10-30%.By contrast, crystalline components were observed in samples with loadings of 40% or higher.These crystalline components were considered to originate predominantly from excess ibuprofen that crystallized outside the mesopores.In the T 1 relaxation analysis using TD-NMR, IBU10-30 was mainly described by a monoexponential function, whereas IBU40-70 required a biexponential function, yielding a long T 1 component associated with crystalline ibuprofen.In the T 2 relaxation analysis, IBU40-70 exhibited an initial rapid decay that was described by a Gaussian function, whereas IBU10-30 showed a gradual exponential decay.The signal proportions of these NMR relaxation components increased with increasing ibuprofen loading and showed trends consistent with the apparent crystallinity estimated by DSC.These results suggest that TD-NMR, particularly T 2 relaxation analysis, may serve as a complementary, nondestructive, and rapid method for evaluating the appearance and increase of crystalline ibuprofen components in mesoporous silica formulations and for monitoring changes in crystallinity.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Madoka Kobayashi"
    },
    {
      "name": "Fumitaka Kato"
    },
    {
      "name": "Kotaro Okada"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c7tgqzf5a5rfv.bib",
  "cited_by": 0,
  "doi": "10.1248/cpb.c26-00368",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/cpb/74/9/74_c26-00368/_article",
  "id": "c7tgqzf5a5rfv",
  "issns": [
    "1347-5223",
    "0009-2363"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/cpb/74/9/74_c26-00368/_article",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "chemistry/medicinal"
    ],
    [
      "openalex",
      "3106|NMR spectroscopy and applications"
    ]
  ],
  "openalex": "W7212046702",
  "pdf_url": "https://www.jstage.jst.go.jp/article/cpb/74/9/74_c26-00368/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c7tgqzf5a5rfv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "10.1248/cpb.c26-00368",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/cpb/74/9/74_c26-00368/_article"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "openalex:3106|NMR spectroscopy and applications",
      "subfield": "high-energy"
    }
  ],
  "title": "Detection of Crystalline Ibuprofen Components in Ibuprofen-Loaded SBA-15 Mesoporous Silica Using Time-Domain NMR",
  "title_text": "Detection of Crystalline Ibuprofen Components in Ibuprofen-Loaded SBA-15 Mesoporous Silica Using Time-Domain NMR",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/c7tgqzf5a5rfv",
  "venue": "Chemical and Pharmaceutical Bulletin",
  "versions": []
}