{
  "abstract": "Perianal ulcers remain challenging to treat because of persistent moisture, high mobility, recurrent infection, and prolonged inflammation at the lesion site. Herein, we developed a mussel-inspired, paintable hydrogel dressing loaded with ginsenoside Rh1 for multifunctional perianal ulcer management. The hydrogel was constructed from dopamine, chitosan, graphene oxide (GO), and polyvinyl alcohol, forming a physically and chemically dual-crosslinked network with robust wet-tissue adhesion, shear-thinning behavior, and structural stability. Optimization of the GO content revealed that the formulation with 0.5 mg/mL GO exhibited the best overall balance of mechanical properties, drug release behavior, and biocompatibility. The hydrogel showed pH-responsive sustained release of Rh1, low hemolysis (<2.45%), good cytocompatibility, antioxidant activity, and rapid hemostatic capability. Under 808 nm near-infrared irradiation, the GO-containing hydrogel also displayed stable photothermal responsiveness and effective antibacterial activity against Escherichia coli and Staphylococcus aureus. In a rat perianal ulcer model, the Rh1-loaded hydrogel significantly accelerated wound repair, achieving a healing rate of 96.78% by day 14. Histological analyses further confirmed enhanced re-epithelialisation, collagen deposition, and tissue remodeling after treatment. These results indicate that the DA/CS/GO/PVA-Rh1 hydrogel is a promising multifunctional dressing for the treatment of difficult-to-heal perianal ulcers.",
  "abstract_shown": true,
  "affiliations": [
    "Weihai Institute for Bionic, Jilin University, Weihai 264402, China.",
    "Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, 5988 Renmin Street, Changchun 130025, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Chaorui Jiang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zezhou Xu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhenglei Yu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c80en9bqn492k.bib",
  "cited_by": 0,
  "doi": "10.3390/biomimetics11100726",
  "fulltext_url": "https://europepmc.org/articles/PMC13702296",
  "id": "c80en9bqn492k",
  "issns": [
    "2313-7673"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930278",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7221527264",
  "pdf_url": "https://europepmc.org/articles/PMC13702296?pdf=render",
  "pmcid": "PMC13702296",
  "pmid": "42930278",
  "published": "2026-10-11",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c80en9bqn492k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930278",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930278"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "A Mussel-Inspired Hydrogel Loaded with Ginsenoside Rh1 for Perianal Ulcer Healing.",
  "title_text": "A Mussel-Inspired Hydrogel Loaded with Ginsenoside Rh1 for Perianal Ulcer Healing.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/c80en9bqn492k",
  "venue": "Biomimetics (Basel, Switzerland)",
  "versions": []
}