{
  "abstract": "Introduction\n\nAmyloid positron emission tomography (PET) is the reference biomarker for treatment target engagement in anti-amyloid beta (Aβ) therapies in early symptomatic Alzheimer's disease (AD), yet global metrics may mask a regional heterogeneity of amyloid clearance.Methods\n\nWe report real-world longitudinal amyloid-PET data from 26 patients treated with lecanemab or donanemab for 6 months. Global Centiloids and regional standardized uptake value ratios (SUVRs) were quantified at baseline and 6 months and examined according to treatment, clinical diagnosis, and clinical stage.Results\n\nAmyloid removal was regionally heterogeneous. Patients with mild cognitive impairment showed greater cortical amyloid reduction than those with mild dementia, while early- and late-onset AD exhibited comparable clearance. Frontal, anterior cingulate, and parietal regions showed the largest SUVR reductions, whereas the occipital cortex and temporal mesial cortex were consistently spared, including in patients reaching global amyloid-PET negativity.Discussion\n\nEarly amyloid clearance following anti-amyloid treatment is regionally heterogeneous and incompletely captured by global PET measures.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Alzheimer's and Related Diseases (CARD) Neurology Unit IRCCS San Raffaele Scientific Institute Milan Italy.",
    "Neuroimaging Research Unit Division of Neuroscience IRCCS San Raffaele Scientific Institute Milan Italy.",
    "Vita-Salute San Raffaele University Milan Italy.",
    "Nuclear Medicine Service IRCCS San Raffaele Scientific Institute Milan Italy.",
    "Neurorehabilitation Unit IRCCS San Raffaele Scientific Institute Milan Italy.",
    "Neurotech Hub Vita-Salute San Raffaele University Milan Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Alma Ghirelli"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Giordano Cecchetti"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Edoardo G Spinelli",
      "orcid": "0000-0003-1492-7221"
    },
    {
      "affs": [
        3
      ],
      "name": "Ana Maria Samanes Gajate"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Giulia Rugarli"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Stefano Pisano"
    },
    {
      "affs": [
        2
      ],
      "name": "Isabella Aurora Lucilla Zamboni"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elisa Canu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Veronica Castelnovo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Elisa Sibilla"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Anna Gilioli"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Chiara Tripodi"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Fabiola Freri"
    },
    {
      "affs": [
        3
      ],
      "name": "Andrea Panzacchi"
    },
    {
      "affs": [
        3
      ],
      "name": "Gino Pepe"
    },
    {
      "affs": [
        3
      ],
      "name": "Arturo Chiti",
      "orcid": "0000-0002-5806-1856"
    },
    {
      "affs": [
        0,
        1,
        2,
        4,
        5
      ],
      "name": "Massimo Filippi"
    },
    {
      "affs": [
        0,
        1,
        2,
        5
      ],
      "name": "Federica Agosta",
      "orcid": "0000-0003-3121-4979"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c86vrf1y1jws4.bib",
  "cited_by": 0,
  "doi": "10.1002/dad2.70448",
  "fulltext_url": "https://europepmc.org/articles/PMC13650510",
  "id": "c86vrf1y1jws4",
  "issns": [
    "2352-8729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42857419",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7221119851",
  "pdf_url": "https://europepmc.org/articles/PMC13650510?pdf=render",
  "pmcid": "PMC13650510",
  "pmid": "42857419",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c86vrf1y1jws4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42857419",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42857419"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Regional amyloid-PET clearance dynamics and anti-Aβ monoclonal antibody therapy: a preliminary real-world study.",
  "title_text": "Regional amyloid-PET clearance dynamics and anti-Aβ monoclonal antibody therapy: a preliminary real-world study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/c86vrf1y1jws4",
  "venue": "Alzheimer's & dementia (Amsterdam, Netherlands)",
  "versions": []
}