{
  "abstract": "Incomplete image‐guided ablation can promote local tumor progression by reshaping the residual tumor microenvironment toward immunosuppression, yet noninvasive biomarkers of this process remain limited. Here, a translational multiparametric PET/MRI strategy was developed to monitor macrophage‐associated microenvironmental remodeling after incomplete microwave ablation (iMWA) in orthotopic VX2 liver tumors. Twenty‐four tumor‐bearing rabbits were assigned to untreated control, early post‐iMWA (short‐term), or late post‐iMWA (long‐term) groups and underwent clinical 3 T PET/MRI, including diffusion‐weighted imaging, dynamic contrast‐enhanced MRI, [1 8F]FDG PET, and T2‐weighted MRI before and after administration of Eu‐VSOP. Eu‐VSOP‐enhanced MRI revealed a hypointense peritumoral rim after iMWA, with the largest rim‐to‐liver signal decrease and rim thickness observed in the long‐term group. Prussian blue staining and LA‐ICP‐ToF‐MS demonstrated preferential iron and europium enrichment in macrophage‐rich, CD206‐associated peritumoral regions. Histology and proteomics further demonstrated increased CD206 and MMP‐9 expression, extracellular matrix remodeling, immunosuppressive myeloid‐associated changes, and metabolic reprogramming in viable residual tumors, accompanied by altered [1 8F]FDG uptake. Together, these findings indicate that incomplete ablation induces a temporally evolving, macrophage‐rich immunosuppressive peritumoral niche and support the potential of Eu‐VSOP‐enhanced multiparametric PET/MRI for noninvasive monitoring of post‐ablation microenvironmental remodeling.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiology Charité – Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt – Universität zu Berlin Berlin Germany",
    "Experimental and Clinical Research Center (ECRC) A Cooperation of Charité – Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine (MDC) Berlin Germany",
    "Department of Nuclear Medicine Campus Virchow‐Klinikum Charité‐Universitätsmedizin Berlin Berlin Germany",
    "Department of Molecular Toxicology German Institute of Human Nutrition Potsdam – Rehbruecke (DIfE) Nuthetal Germany",
    "Berlin Institute of Health at Charité – Universitätsmedizin Berlin Berlin Germany",
    "Berlin Experimental Radionuclide Imaging Center (BERIC, RRID: SCR_028573) Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin Berlin Germany",
    "Helmholtz – Zentrum Dresden – Rossendorf, PET Center Institute of Radiopharmaceutical Cancer Research Dresden Germany",
    "Department of Diagnostic and Interventional Radiology Technical University of Munich Munich Germany",
    "Core Facility High – Throughput Mass Spectrometry Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt – Universität zu Berlin Berlin Germany",
    "Charité – Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt – Universität zu Berlin Berlin Germany",
    "Max Delbrück Center for Molecular Medicine in the Helmholtz Association Berlin Germany",
    "Bundesanstalt für Materialforschung und – prüfung (BAM) Berlin Germany",
    "Freie Universität Berlin Institute of Geological Sciences Berlin Germany",
    "Department of Radiology and Nuclear Medicine Otto – von – Guericke University Magdeburg Magdeburg Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yubei He",
      "orcid": "0000-0001-6224-2441"
    },
    {
      "affs": [
        0
      ],
      "name": "Han Xu",
      "orcid": "0009-0000-8119-1475"
    },
    {
      "affs": [
        2
      ],
      "name": "Julian M. M. Rogasch",
      "orcid": "0000-0002-0817-6532"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Nikolaus Berndt",
      "orcid": "0000-0001-5594-9940"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Guo",
      "orcid": "0000-0002-1170-8157"
    },
    {
      "affs": [
        0
      ],
      "name": "Eyk Schellenberger",
      "orcid": "0000-0003-4096-6865"
    },
    {
      "affs": [
        0
      ],
      "name": "Akvile Häckel",
      "orcid": "0009-0001-7398-056X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Luisa Heidemann",
      "orcid": "0009-0003-6153-4110"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Friederike Hesse",
      "orcid": "0000-0001-5427-7564"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yu Liu",
      "orcid": "0009-0004-2581-1819"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Justus Ramtke",
      "orcid": "0009-0009-6010-8340"
    },
    {
      "affs": [
        5
      ],
      "name": "Nicola Beindorff",
      "orcid": "0000-0001-9126-3356"
    },
    {
      "affs": [
        6
      ],
      "name": "Frank Hofheinz"
    },
    {
      "affs": [
        0,
        7
      ],
      "name": "Avan Kader",
      "orcid": "0000-0002-5453-1267"
    },
    {
      "affs": [
        8
      ],
      "name": "Michael Mülleder",
      "orcid": "0000-0001-9792-3861"
    },
    {
      "affs": [
        8
      ],
      "name": "Kathrin Textoris‐Taube"
    },
    {
      "affs": [
        0
      ],
      "name": "Bernd Hamm"
    },
    {
      "affs": [
        1,
        9,
        10
      ],
      "name": "Dominik N. Müller",
      "orcid": "0000-0003-3650-5644"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Robin Schmidt",
      "orcid": "0000-0003-0012-2799"
    },
    {
      "affs": [
        0
      ],
      "name": "Ralf Hauptmann",
      "orcid": "0000-0002-0795-2595"
    },
    {
      "affs": [
        11
      ],
      "name": "Heike Traub",
      "orcid": "0000-0001-9937-9476"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Mathias Schannor",
      "orcid": "0000-0003-2990-1331"
    },
    {
      "affs": [
        0,
        1,
        4,
        13
      ],
      "name": "Lynn Jeanette Savic",
      "orcid": "0000-0003-2115-6728"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c8tk9qgpgx9c8.bib",
  "cited_by": 0,
  "doi": "10.1002/advs.78490",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735433/",
  "id": "c8tk9qgpgx9c8",
  "issns": [
    "2198-3844"
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  "landing_url": "https://doi.org/10.1002/advs.78490",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2403|Immune cells in cancer"
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  "openalex": "W7225333614",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.78490",
  "pmcid": "PMC13735433",
  "pmid": "42985824",
  "published": "2026-11-05",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/c8tk9qgpgx9c8.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:07Z",
      "native_id": "PMC13735433",
      "source": "pmc",
      "url": "https://doi.org/10.1002/advs.78490"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immune cells in cancer",
      "subfield": "immunology"
    }
  ],
  "title": "Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer",
  "title_text": "Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:07Z",
  "url": "https://research.draconitic.com/paper/c8tk9qgpgx9c8",
  "venue": "Advanced Science",
  "versions": []
}