{
  "abstract": "Aging, neuroinflammation and metabolic dysfunction are tightly intertwined in Alzheimer's disease (AD), but how transient pathological signals become persistent cellular states remains poorly understood. Histone post‐translational modifications (PTMs) provide a dynamic interface between extracellular stimuli, cellular metabolism and chromatin state. This Review examines how canonical histone modifications and emerging metabolite‐derived acylations regulate inflammatory and stress‐responsive programmes across microglia, astrocytes and neurons during aging and AD. We discuss how amyloid‐β, tau pathology, metabolic dysfunction and innate immune signaling converge on histone‐modifying machinery, and how reciprocal interactions between metabolism and chromatin may stabilize disease‐associated cell states. Particular attention is given to cellular senescence and neuroimmune memory, while emphasizing the context dependence of individual histone marks across cell types, genomic regions and disease stages. We further evaluate evidence for causality using three criteria: perturbation, persistence and reversibility. This framework distinguishes chromatin states that accompany ongoing pathology from those capable of sustaining pathological cell states beyond their initiating signals. Finally, we consider therapeutic strategies targeting histone‐modifying enzymes, chromatin readers and metabolic inputs to restore chromatin plasticity and promote resolution of chronic neuroinflammation.",
  "abstract_shown": true,
  "affiliations": [
    "Heilongjiang University of Chinese Medicine Harbin Heilongjiang Province China",
    "The First Affiliated Hospital of Jiamusi University Jiamusi Heilongjiang Province China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Junyi Liang",
      "orcid": "0009-0000-3011-5819"
    },
    {
      "affs": [
        0
      ],
      "name": "Huawen Cao"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiumin Ren"
    },
    {
      "affs": [
        0
      ],
      "name": "Nan Sha"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueqing Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Ling Jiang",
      "orcid": "0000-0003-3331-6207"
    },
    {
      "affs": [
        0
      ],
      "name": "Bin Liu",
      "orcid": "0000-0001-6884-4726"
    },
    {
      "affs": [
        0
      ],
      "name": "Weiming Zhao",
      "orcid": "0000-0003-1287-9975"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c957gsqc67x8b.bib",
  "cited_by": 0,
  "doi": "10.1111/acel.70785",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710670/",
  "id": "c957gsqc67x8b",
  "issns": [
    "1474-9718",
    "1474-9726"
  ],
  "landing_url": "https://doi.org/10.1111/acel.70785",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
    [
      "openalex",
      "2737|Alzheimer's disease research and treatments"
    ]
  ],
  "openalex": "W7223982763",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/acel.70785",
  "pmcid": "PMC13710670",
  "pmid": "42934178",
  "published": "2026-10-26",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/c957gsqc67x8b.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:35Z",
      "native_id": "PMC13710670",
      "source": "pmc",
      "url": "https://doi.org/10.1111/acel.70785"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease",
  "title_text": "Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:35Z",
  "url": "https://research.draconitic.com/paper/c957gsqc67x8b",
  "venue": "Aging Cell",
  "versions": []
}