{
  "abstract": "This study aimed to evaluate the sensitivity of synovial fluid (SF) white blood cell count (SF-WBC), SF polymorphonuclear neutrophil percentage (PMN%), and the SF/serum glucose ratio in a study population with a definitive diagnosis of hematogenous native joint septic arthritis (SA) and explore factors influencing their performance, including the causative pathogen. We conducted a retrospective register and medical record study of 57 patients with culture-verified hematogenous native joint SA identified through ICD-codes between 2016 and 2019 in western Sweden. All patients included had documented SF-WBC analysis. Clinical data and SF analyses were compared between patients above and below cutoffs for SF-WBC (50,000 cells/mm ³ ) and SF/serum glucose ratio of 0.5. SF findings were also compared between S. aureus and other pathogens. The sensitivity of SF-WBC ≥ 50,000 cells/mm ³ was 51%, SF/serum glucose ratio < 0.5 was 57% and PMN% ≥ 70 was 95%. Patients with SF-WBC ≥ 50,000 cells/mm ³ were significantly older. SA caused by S. aureus were associated with lower PMN% and higher SF/serum glucose ratio compared to other organisms. While PMN ≥ 70% had a high sensitivity for native joint SA, the conventional cutoffs for SF-WBC and SF/serum glucose ratio showed poor sensitivity. SA caused by S. aureus may be associated with a less pronounced inflammatory response compared with other pathogens, a finding that warrants further investigation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Hanna Alexandersson"
    },
    {
      "name": "Jonatan Tillander"
    },
    {
      "name": "Mats Dehlin"
    },
    {
      "name": "Tao Jin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c9e2eea5n9aks.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-75208-6",
  "fulltext_url": null,
  "id": "c9e2eea5n9aks",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-75208-6",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Orthopedic Infections and Treatments"
    ]
  ],
  "openalex": "W7222654705",
  "pdf_url": "https://www.nature.com/articles/s41598-026-75208-6.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-16",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/c9e2eea5n9aks.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:30Z",
      "native_id": "10.1038/s41598-026-75208-6",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-75208-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Orthopedic Infections and Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Sensitivity of synovial fluid analysis in hematogenous native joint septic arthritis – overall accuracy and pathogen-specific differences",
  "title_text": "Sensitivity of synovial fluid analysis in hematogenous native joint septic arthritis – overall accuracy and pathogen-specific differences",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:30Z",
  "url": "https://research.draconitic.com/paper/c9e2eea5n9aks",
  "venue": "Scientific Reports",
  "versions": []
}