{
  "abstract": "Macrophage lipid metabolism is a pivotal regulator of bone homeostasis. Macrophages orchestrate the balance between bone resorption and formation primarily through their M1/M2 polarization states, with M1 macrophages promoting resorption and M2 macrophages supporting formation. This review comprehensively describes how key lipid metabolic pathways, such as fatty acid oxidation (FAO) and cholesterol metabolism, govern this polarization and subsequent bone remodeling. It integrates the core mechanisms by which lipid metabolism drives M1 and M2 polarization, and highlights that targeting macrophage lipid metabolism represents a promising therapeutic strategy for bone diseases. Finally, we identify emerging frontiers, including the \"gut-bone axis\" and epigenetic regulation, as critical directions for future research.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.",
    "School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.",
    "Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, PR China.",
    "Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. maojing@hust.edu.cn.",
    "School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. maojing@hust.edu.cn.",
    "Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, PR China. maojing@hust.edu.cn.",
    "Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. songke_coco@163.com.",
    "School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. songke_coco@163.com.",
    "Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, PR China. songke_coco@163.com.",
    "Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. qilinli@tjh.tjmu.edu.cn.",
    "School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. qilinli@tjh.tjmu.edu.cn.",
    "Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, PR China. qilinli@tjh.tjmu.edu.cn."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Longping Li"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yuxiao Zhang"
    },
    {
      "affs": [
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        1,
        2
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      "name": "Shuo Huang"
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    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yang Xiao"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Genyu Liu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Zhengjie Wu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yiqian Hu"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shiqiang Gong",
      "orcid": "0000-0001-9796-4081"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Jing Mao"
    },
    {
      "affs": [
        6,
        7,
        8
      ],
      "name": "Ke Song"
    },
    {
      "affs": [
        9,
        10,
        11
      ],
      "name": "Qilin Li",
      "orcid": "0000-0001-7715-7848"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c9nkdhfjb0g5k.bib",
  "cited_by": 0,
  "doi": "10.1038/s41413-026-00590-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13722702",
  "id": "c9nkdhfjb0g5k",
  "issns": [
    "2095-4700",
    "2095-6231"
  ],
  "landing_url": "https://europepmc.org/article/MED/42963349",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review Article"
    ],
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      "openalex",
      "1312|Bone Metabolism and Diseases"
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  "openalex": "W7224818780",
  "pdf_url": "https://europepmc.org/articles/PMC13722702?pdf=render",
  "pmcid": "PMC13722702",
  "pmid": "42963349",
  "published": "2026-10-30",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/c9nkdhfjb0g5k.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T03:21:21Z",
      "native_id": "MED:42963349",
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      "url": "https://europepmc.org/article/MED/42963349"
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    {
      "first_seen": "2026-11-04T12:21:28Z",
      "native_id": "PMC13722702",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41413-026-00590-w"
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Bone Metabolism and Diseases",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Metabolic reprogramming in macrophages: the central role of lipid metabolism in bone homeostasis.",
  "title_text": "Metabolic reprogramming in macrophages: the central role of lipid metabolism in bone homeostasis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:28Z",
  "url": "https://research.draconitic.com/paper/c9nkdhfjb0g5k",
  "venue": "Bone research",
  "versions": []
}