{
  "abstract": "Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by a dense stroma that impedes drug penetration and establishes an immune-“cold” microenvironment. Conventional external beam radiotherapy is often limited by off-target toxicity to surrounding normal tissues due to the complex anatomy of the pancreas. Boron neutron capture therapy (BNCT) is a binary targeted radiotherapy that utilizes a focused thermal neutron beam to trigger the in situ production of high-energy particles, enabling single-cell-scale tumor cell ablation. However, the efficacy of BNCT in PDAC critically depends on the ability of B-10 carriers to effectively penetrate the dense stromal barrier and achieve efficient internalization into tumor cells. Herein, we developed nine αvβ6 integrin-targeting peptide‒BSH conjugates to optimize the BNCT therapeutic index. By optimizing linker structure and the number of BSH moieties, amphiphilic agents with enhanced PDAC cellular uptake were obtained. The lead compound, namely DOTA-2BB, adopts a “trident-shaped” structure that facilitates stromal penetration and exhibits the optimal tumor uptake and retention. In a PDAC mouse model, administration of DOTA-2BB followed by thermal neutron irradiation resulted in suppression of tumor growth with favorable biosafety. These findings establish DOTA-2BB as a promising B-10 carrier for PDAC and provide a strategy for treating stroma-rich tumors.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China",
    "Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China",
    "Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences & Research Unit of Peptide Science, Chinese Academy of Medical Sciences, Lanzhou University, Lanzhou 730000, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Linger Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Siqi Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xingkai Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueyao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuan Miao"
    },
    {
      "affs": [
        0
      ],
      "name": "Tongtong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengjie Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Can Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Tianjiao Liang"
    },
    {
      "affs": [
        1
      ],
      "name": "Tiancheng Yi"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuo Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongyi Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Hailong Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianfei Tong"
    },
    {
      "affs": [
        0
      ],
      "name": "Rui Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Kuan Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c9s83hv1hrh17.bib",
  "cited_by": 0,
  "doi": "10.1016/j.apsb.2026.05.012",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729520/?tool=EBI",
  "id": "c9s83hv1hrh17",
  "issns": [
    "2211-3835",
    "2211-3843"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13729520",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2741|Boron Compounds in Chemistry"
    ]
  ],
  "openalex": "W7161691531",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729520/pdf/?tool=EBI",
  "pmcid": "PMC13729520",
  "pmid": "42979061",
  "published": "2026-05-19",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/c9s83hv1hrh17.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "PMC:PMC13729520",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13729520"
    },
    {
      "first_seen": "2026-11-07T12:22:15Z",
      "native_id": "PMC13729520",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.apsb.2026.05.012"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Boron Compounds in Chemistry",
      "subfield": "imaging"
    }
  ],
  "title": "Engineered αvβ6-targeting peptide‒BSH conjugates for boron neutron capture therapy of pancreatic ductal adenocarcinoma",
  "title_text": "Engineered αvβ6-targeting peptide‒BSH conjugates for boron neutron capture therapy of pancreatic ductal adenocarcinoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:15Z",
  "url": "https://research.draconitic.com/paper/c9s83hv1hrh17",
  "venue": "Acta pharmaceutica Sinica. B",
  "versions": []
}