{
  "abstract": "Background: Chronic and ischemic wounds are dysregulated, causing inflammation, oxidative stress, and bacterial colonization. This work developed a bionanocomposite hydrogel using biogenic selenium nanoparticles (SeNPs) to encapsulate and topically distribute two weakly water-soluble medicines, curcumin (Curc) and simvastatin (SMV), to improve wound healing. Methods: Green production of biogenic SeNPs utilizing Psidium guajava (guava) leaf extract. Based on entrapment efficiency (%EE; E1) and cumulative drug release after 2 and 8 h (E2) and (E3), a two-factor, three-level Box-Behnken design selected the SeNP-to-drug weight ratio (C₁) and ethanol concentration (C₂). The selected nanoconstruct was integrated into a 2% w/v Carbopol 934 hydrogel and characterized by UV-vis, FTIR, SEM, and DLS. In a 14-day full-thickness excisional wound model in Wistar rats, wound contraction, tissue remodeling, inflammatory responses, and healing kinetics were examined to determine its therapeutic efficiency. Results: Formulation F9 had the highest overall attractiveness (0.998) and %EE values of 94.71% for SMV and 93.92% for Curc. DLS showed a hydrodynamic particle size of 177.7 nm and PDI of 0.41. Both medications were successfully incorporated without chemical incompatibility based on FTIR analysis. The selected nanogel maintained a skin-friendly pH of 6.2 ± 0.1 and sustained biphasic drug release. In vivo, the half-dose nanogel showed an enhanced wound-healing response, accelerating wound contraction and achieving complete epithelialization in 14 ± 1.06 days (p < 0.05) compared to 22 ± 2.5 days for the sham control, corresponding to a 36% reduction in healing time. Histopathology showed epidermal thickness restoration and well-organized collagen deposition. In addition, therapy dramatically decreased the proinflammatory biomarkers IL-1β, MMP-9, and COX-2 and increased IL-10 levels without causing tissue discomfort. Conclusions: The biogenic SeNP-based nanogel delivers Curc and SMV locally with prolonged drug release and anti-inflammatory and tissue-remodeling effects. The half-dose combination accelerated wound healing while retaining tissue compatibility, suggesting this green nanocomposite hydrogel could be a promising topical method for advanced cutaneous wound therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.",
    "Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag National University, Sohag 82524, Egypt.",
    "Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.",
    "Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt.",
    "Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag National University, Sohag 82524, Egypt.",
    "Department of Pharmacology and Toxicology, Faculty of Pharmacology, Sohag University, Sohag 82524, Egypt.",
    "Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, New Valley University, Al-Kharga 72511, Egypt.",
    "Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, New Valley National University, Al-Kharga 72511, Egypt."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Nahla A Kasem",
      "orcid": "0009-0008-1589-9860"
    },
    {
      "affs": [
        2
      ],
      "name": "Hatem A Sarhan"
    },
    {
      "affs": [
        2
      ],
      "name": "Mahmoud Mostafa",
      "orcid": "0000-0001-6425-9247"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Heba A Hofny"
    },
    {
      "affs": [
        5
      ],
      "name": "Deiaa E Elsayed Abouzed"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Mahmoud M A Elsayed",
      "orcid": "0000-0001-9547-2243"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Mahmoud Elkot Mostafa",
      "orcid": "0009-0002-5378-100X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/c9zrc087mjke5.bib",
  "cited_by": 0,
  "doi": "10.3390/pharmaceutics18101257",
  "fulltext_url": "https://europepmc.org/articles/PMC13708416",
  "id": "c9zrc087mjke5",
  "issns": [
    "1999-4923"
  ],
  "landing_url": "https://europepmc.org/article/MED/42942789",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7220384866",
  "pdf_url": "https://europepmc.org/articles/PMC13708416?pdf=render",
  "pmcid": "PMC13708416",
  "pmid": "42942789",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/c9zrc087mjke5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:24Z",
      "native_id": "MED:42942789",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42942789"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Biogenic Selenium Nanoparticle-Based Nanocomposite Hydrogel for Dual Delivery of Curcumin and Simvastatin for Topical Wound Healing Applications.",
  "title_text": "Biogenic Selenium Nanoparticle-Based Nanocomposite Hydrogel for Dual Delivery of Curcumin and Simvastatin for Topical Wound Healing Applications.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:24Z",
  "url": "https://research.draconitic.com/paper/c9zrc087mjke5",
  "venue": "Pharmaceutics",
  "versions": []
}