{
  "abstract": "Aims: To describe the pharmacokinetics of vancomycin in patients requiring intermittent haemodialysis (iHD) and provide guidance for optimised dosing for a three-times-weekly post-iHD regimen. Methods: A population pharmacokinetic study using retrospectively collected data was conducted in a remote Australian dialysis centre. Adult patients receiving post-iHD vancomycin therapy between 1st January 2017 and 31st July 2023 were screened. Inclusion criteria: ≥ 3 months of iHD, prescribed vancomycin, and recorded ≥ 1 vancomycin concentration. Pharmacokinetic analysis was performed using Monolix. The probability of pharmacokinetic/pharmacodynamic target attainment (PTA) for pre-iHD trough concentrations of 15-20 mg/L was simulated for various loading and maintenance doses. Results: A total of 302 vancomycin concentrations were available from 80 courses (58 patients, 45 were female) with a median age of 52 (IQR 45-61) years and weight of 75 (66.5-85.5) kg. A one-compartment model adequately described the data. Actual body weight was the only covariate retained in the final model. The estimated vancomycin clearance during non-iHD periods, during iHD periods, and volume of distribution were 0.54 L/h, 4.84 L/h, and 87.02 L, respectively. The simulations supported weight-based loading doses. The time to the next iHD session also significantly influenced the PTA of loading doses. Subjects with higher weight required lower weight-based doses, and vice versa. The PTA of maintenance doses was associated with the pre-iHD trough concentrations and the dosing intervals. Weight had a limited impact on the PTA of maintenance doses. Conclusion: A comprehensive vancomycin dosing nomogram was suggested for patients requiring iHD. Validation in future prospective studies is recommended.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Danny Tsai"
    },
    {
      "name": "María Patricia Hernández-Mitre"
    },
    {
      "name": "Amy Legg"
    },
    {
      "name": "Jacqueline Martin"
    },
    {
      "name": "Cherian Sajiv"
    },
    {
      "name": "Sachin Kodgire"
    },
    {
      "name": "William Naughton"
    },
    {
      "name": "Sonja Janson"
    },
    {
      "name": "Jaquelyne Hughes"
    },
    {
      "name": "Xin Liu"
    },
    {
      "name": "Jason Roberts"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ca50b514jxaev.bib",
  "cited_by": 0,
  "doi": "10.1111/nep.70239",
  "fulltext_url": null,
  "id": "ca50b514jxaev",
  "issns": [
    "1320-5358",
    "1440-1797"
  ],
  "landing_url": "https://hal.science/hal-05774848v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "openalex",
      "2736|Antibiotics Pharmacokinetics and Efficacy"
    ]
  ],
  "openalex": "W7166531431",
  "pdf_url": "https://hal.science/hal-05774848/document",
  "pmcid": null,
  "pmid": "42366866",
  "published": "2026-06-29",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/ca50b514jxaev.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:46Z",
      "native_id": "hal-05774848",
      "source": "hal",
      "url": "https://hal.science/hal-05774848v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Antibiotics Pharmacokinetics and Efficacy",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Optimising Therapeutic Target Attainment in Vancomycin Therapy for Patients Requiring Intermittent Haemodialysis",
  "title_text": "Optimising Therapeutic Target Attainment in Vancomycin Therapy for Patients Requiring Intermittent Haemodialysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:46Z",
  "url": "https://research.draconitic.com/paper/ca50b514jxaev",
  "venue": "Nephrology",
  "versions": []
}