{
  "abstract": "Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuronal injury. Cannabidiol (CBD), a non-psychoactive constituent of Cannabis sativa L., has neuroprotective potential, but its underlying mechanisms remain unclear. Purpose: This study investigated the effects of CBD on Aβ1–42-induced cognitive impairment and hippocampal injury, focusing on endocannabinoid and BDNF/TrkB signaling. Methods: Cognitive function was assessed by Morris water maze and novel object recognition tests; hippocampal pathology and molecular changes were evaluated by H&E staining, immunofluorescence, LC–MS, ELISA, and Western blotting; and CB1R involvement was further examined in Aβ1–42-treated PC12 cells using AM251. Results: CBD improved cognitive performance, attenuated hippocampal histopathological alterations, reduced tau hyperphosphorylation, and partially restored synaptophysin levels. CBD also increased hippocampal AEA levels, reduced FAAH levels, and restored CB1R and BDNF/TrkB-associated signaling. In Aβ1–42-treated PC12 cells, CBD improved cell viability and increased synaptophysin, CB1R, BDNF, and p-TrkB/TrkB levels, whereas AM251 attenuated several CBD-associated effects. Conclusions: These findings suggest that modulation of the AEA–FAAH–CB1R axis and BDNF/TrkB signaling may contribute to the neuroprotective effects of CBD against Aβ1–42-induced cognitive impairment and neuronal injury.",
  "abstract_shown": true,
  "affiliations": [
    "Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China",
    "Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yan Kong"
    },
    {
      "affs": [
        0
      ],
      "name": "Juan Peng"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Yinglan Nie"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/caj0sf5ac92p5.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16101473",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702573/?tool=EBI",
  "id": "caj0sf5ac92p5",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/10/1473",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Cannabis and Cannabinoid Research"
    ]
  ],
  "openalex": "W7221326069",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13702573/pdf/?tool=EBI",
  "pmcid": "PMC13702573",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/caj0sf5ac92p5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16101473",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/10/1473"
    },
    {
      "first_seen": "2026-10-30T12:21:34Z",
      "native_id": "PMC:PMC13702573",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13702573"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Cannabis and Cannabinoid Research",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Cannabidiol Alleviates Aβ1–42-Induced Cognitive Deficits and Neuronal Injury Associated with Modulation of the AEA–FAAH–CB1R Axis and BDNF/TrkB Signaling",
  "title_text": "Cannabidiol Alleviates Aβ1–42-Induced Cognitive Deficits and Neuronal Injury Associated with Modulation of the AEA–FAAH–CB1R Axis and BDNF/TrkB Signaling",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:34Z",
  "url": "https://research.draconitic.com/paper/caj0sf5ac92p5",
  "venue": "Biomolecules",
  "versions": []
}