{
  "abstract": "Many solid tumors remain refractory to immunotherapy due to profoundly immunosuppressive tumor microenvironments. Although vagus nerve stimulation offers a direct neural axis to reprogram immune function, its potential in cancer immunotherapy remains unrealized due to the absence of stable, system-level neuromodulation platforms. Herein, we develop a miniature subdiaphragmatic vagus nerve stimulator (SVNS) for near-organ neuromodulation of pancreatic tumor immunity. To construct stable electrical coupling with subdiaphragmatic vagus nerve (SVN) along the esophagus, a dynamically adaptive neural interface comprising an injectable anti-fatigue adhesive conductive hydrogel and a deformable liquid metal electrode is explored. The SVNS is integrated with a battery-free lead-free wireless power module, which can be configured into a Swiss-roll architecture, enabling minimally invasive implantation. In an orthotopic mouse model of pancreatic tumor, chronic SVN stimulation using SVNS suppressed tumor growth and metastasis, reshaped tumor innervation, promoted a shift toward an M1-like TAM phenotype, enhanced cytotoxic immune cell infiltration, and further potentiated the efficacy of anti-PD-1 immunotherapy.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 18,
  "authors": [
    {
      "name": "Wenliang Liu"
    },
    {
      "name": "Jingjie Liu",
      "orcid": "0000-0002-1037-2591"
    },
    {
      "name": "Renyuan Sun"
    },
    {
      "name": "Ming Yang"
    },
    {
      "name": "Dingke Zhang"
    },
    {
      "name": "Kun Yang"
    },
    {
      "name": "Weixian Xu",
      "orcid": "0009-0001-0054-4687"
    },
    {
      "name": "Chuan Gao"
    },
    {
      "name": "Shihao Wang"
    },
    {
      "name": "Ziyu Zhang"
    },
    {
      "name": "Qiong Wang"
    },
    {
      "name": "Wenyuan Wang"
    },
    {
      "name": "Qingya Liu"
    },
    {
      "name": "Li Zhang",
      "orcid": "0000-0003-1620-1512"
    },
    {
      "name": "Jiexiong Feng",
      "orcid": "0009-0008-7135-5227"
    },
    {
      "name": "Xiangliang Yang",
      "orcid": "0000-0003-0683-8763"
    },
    {
      "name": "Lu Gan",
      "orcid": "0000-0002-8785-867X"
    },
    {
      "name": "Zhiqiang Luo",
      "orcid": "0000-0003-3867-6607"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cap890cqsf88r.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-79002-w",
  "fulltext_url": null,
  "id": "cap890cqsf88r",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-79002-w",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2808|Vagus Nerve Stimulation Research"
    ]
  ],
  "openalex": "W7223651403",
  "pdf_url": "https://www.nature.com/articles/s41467-026-79002-w_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/cap890cqsf88r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:39Z",
      "native_id": "10.1038/s41467-026-79002-w",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-79002-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2808|Vagus Nerve Stimulation Research",
      "subfield": "neurology"
    }
  ],
  "title": "Dynamically adaptive soft bioelectronics for neuro-immunomodulatory cancer therapy",
  "title_text": "Dynamically adaptive soft bioelectronics for neuro-immunomodulatory cancer therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:39Z",
  "url": "https://research.draconitic.com/paper/cap890cqsf88r",
  "venue": "Nature Communications",
  "versions": []
}