{
  "abstract": "Aedes aegypti is a major vector of several arboviral diseases, and understanding its global genetic diversity is critical for effective control strategies. The mitochondrial cytochrome c oxidase subunit I (COI) gene is widely used in population genetics due to its relatively rapid mutation rate and maternal inheritance. This study analyzed 480 mitochondrial cytochrome c oxidase subunit I (COI) gene sequences from five continents (Africa, Asia, Europe, North America, and South America) to investigate genetic diversity, population structure, and phylogeographic patterns. A total of 96 haplotypes, 197 polymorphic sites, and 214 mutations were identified. High global haplotype diversity (Hd = 0.934) and nucleotide diversity (π = 0.08596) indicate substantial genetic variation. Africa exhibited the highest haplotype diversity, while Asia showed the highest nucleotide diversity. The haplotype network revealed 83 unique haplotypes and only 13 shared haplotypes, including a globally distributed lineage (Hap_9), suggesting both local diversification and long-distance dispersal. Phylogenetic analysis revealed two weakly supported clades, with most haplotypes forming a single mixed cluster, indicating limited phylogeographic structure. However, population genetic analyses showed significant differentiation among continents (FST = 0.18789, P < 0.001), with most variation occurring within populations (81.21%). Moderate gene flow (Nm = 1.08), together with a weak but significant isolation-by-distance pattern, further indicates partial connectivity among populations. Overall, the results highlight a complex global genetic landscape shaped by historical dispersal, human-mediated movement, and regional evolutionary processes. These findings provide valuable insights for improving vector surveillance and control strategies worldwide.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Zoology, University of Chittagong",
    "Department of Computer Science and Engineering, University of Chittagong",
    "Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Md. Ahashan Habib Siam"
    },
    {
      "affs": [
        0
      ],
      "name": "D. Dey"
    },
    {
      "affs": [
        0
      ],
      "name": "J. K. Owaresat"
    },
    {
      "affs": [
        1
      ],
      "name": "Yousha Shamim Khan"
    },
    {
      "affs": [
        2
      ],
      "name": "AMAM Zonaed Siddiki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/casz10dgpm2rh.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-63433-y",
  "fulltext_url": "https://doi.org/10.1038/s41598-026-63433-y",
  "id": "casz10dgpm2rh",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://doi.org/10.1038/s41598-026-63433-y",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "Q"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "openalex",
      "1311|Genetic diversity and population structure"
    ]
  ],
  "openalex": "W7171959584",
  "pdf_url": "https://www.nature.com/articles/s41598-026-63433-y_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/casz10dgpm2rh.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T14:21:19Z",
      "native_id": "011b8ae660574f869a1795eaddcaf004",
      "source": "doaj",
      "url": "https://doi.org/10.1038/s41598-026-63433-y"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic diversity and population structure",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Mitochondrial COI reveals pronounced geographic structuring and limited gene flow in global Aedes aegypti populations",
  "title_text": "Mitochondrial COI reveals pronounced geographic structuring and limited gene flow in global Aedes aegypti populations",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T14:20:46Z",
  "url": "https://research.draconitic.com/paper/casz10dgpm2rh",
  "venue": "Scientific Reports",
  "versions": []
}