{
  "abstract": "Background/Objectives: To evaluate the two-year efficacy and safety of PreserFlo MicroShunt (PMS) implantation in an Asian cohort with primary open-angle glaucoma via post hoc exploratory comparison of standalone PMS versus combined phacoemulsification and PMS (PMS+Phaco). Methods: This prospective single-centre cohort study included 30 consecutive eyes of 30 patients who underwent PMS implantation and were followed for 24 months. Nine eyes underwent standalone PMS and 21 underwent PMS+Phaco. The primary outcome was surgical success assessed using Kaplan–Meier survival analysis. Qualified success was defined as intraocular pressure (IOP) of 6–21 mmHg with ≥20% reduction from baseline, with or without IOP-lowering medication; complete success required no glaucoma medications. Failure was defined as not meeting success criteria at two consecutive visits, with the earliest failure at 3 months. WGA-style definitions were retained to ensure comparison with the published literature. Results: Median age was 73 years (IQR 70–78), baseline IOP was 16.0 mmHg (14.0–18.4), and patients were using a median of 3 (2–3) IOP-lowering medications. At 24 months, median IOP was 15.0 mmHg (13.0–17.1), with 57% of eyes remaining medication-free. Whole-cohort qualified success at 24 months was 36.7% (95% CI 20.1–53.4). Qualified success was 44.4% (95% CI 13.6–71.9) for standalone PMS and 33.3% (14.9–53.1) for PMS+Phaco (log-rank p = 0.586). Using alternative IOP thresholds, 83.2% of eyes achieved qualified success at IOP < 18 mmHg and 76.5% did so below the cohort baseline mean of 16.5 mmHg. Corneal oedema was more frequent after combined surgery (38.1% vs. 0%). Bleb needling was required in 40% of eyes. Conclusions: PMS implantation, performed alone or with phacoemulsification, was associated with sustained reduction in medication burden, with 57% of eyes remaining medication-free at 24 months. Absolute IOP control over 24 months was modest. In post hoc exploratory analysis, no difference in surgical success was detected between procedural approaches; however, confidence intervals were wide and data were insufficient to establish equivalence. Low success rates using conventional criteria likely reflect the cohort’s relatively low baseline IOP (median 16.0 mmHg).",
  "abstract_shown": true,
  "affiliations": [
    "Singapore National Eye Centre, Singapore 168751, Singapore",
    "UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK",
    "Singapore Eye Research Institute, Singapore 169856, Singapore",
    "Duke-NUS Medical School, Singapore 169857, Singapore",
    "NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1V 2PD, UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Abdus Samad Ansari",
      "orcid": "0000-0002-5135-8032"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yamon Thant Syn"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Phey Feng Lo"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhu Li Yap",
      "orcid": "0000-0002-4110-7539"
    },
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Paul J. Foster"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Shamira A. Perera",
      "orcid": "0000-0002-1404-5096"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Tina T. Wong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cavmmfhd6gtqb.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15207791",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705064/?tool=EBI",
  "id": "cavmmfhd6gtqb",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/7791",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Glaucoma and retinal disorders"
    ]
  ],
  "openalex": "W7221136393",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705064/pdf/?tool=EBI",
  "pmcid": "PMC13705064",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/cavmmfhd6gtqb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15207791",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/7791"
    },
    {
      "first_seen": "2026-10-30T12:21:45Z",
      "native_id": "PMC:PMC13705064",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705064"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Glaucoma and retinal disorders",
      "subfield": "general"
    }
  ],
  "title": "PreserFlo MicroShunt Outcomes in Asia: Two-Year Results with Exploratory Comparisons of Standalone and Combined Surgery from a Regional Tertiary Centre",
  "title_text": "PreserFlo MicroShunt Outcomes in Asia: Two-Year Results with Exploratory Comparisons of Standalone and Combined Surgery from a Regional Tertiary Centre",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:45Z",
  "url": "https://research.draconitic.com/paper/cavmmfhd6gtqb",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}