{
  "abstract": "Five undescribed compounds, including two drimane-type sesquiterpenoids, asperdrimanes A and B (1 and 2), and three amide compounds, asperspamides A-C (3-5), together with four known metabolites 6-9, were isolated from the fungus Aspergillus spelaeus GDGJ-286. By extensively analyzing NMR, LC-MS/MS, Marfey's method, and X-ray crystallography, the structures were characterized successfully. Asperdrimanes A and B (1 and 2) are drimane-type sesquiterpenoids characterized by a spiro-β-lactone moiety. Asperspamide B (4) exhibited exceptional antioxidant capacity in ABTS, FRAP, and DPPH tests, along with significant neuroprotective effects in a hydrogen peroxide-induced PC12 cell oxidative injury model, demonstrating strong anti-apoptotic and anti-necrotic properties. These findings highlight asperspamide B's potential as a lead compound for developing antioxidant agents.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Jia-Tong Zhou"
    },
    {
      "name": "Min Wang"
    },
    {
      "name": "Qian Wu"
    },
    {
      "name": "Min Liang"
    },
    {
      "name": "Wei-Feng Xu",
      "orcid": "0009-0004-2590-4820"
    },
    {
      "name": "Jun Li"
    },
    {
      "name": "Li-Jun Zhang"
    },
    {
      "name": "Rui-Yun Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/caw3kexpc3p8n.bib",
  "cited_by": 0,
  "doi": "10.1007/s13659-026-00637-9",
  "fulltext_url": "https://europepmc.org/articles/PMC13728077",
  "id": "caw3kexpc3p8n",
  "issns": [
    "2192-2195",
    "2192-2209"
  ],
  "landing_url": "https://europepmc.org/article/MED/42970221",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2736|Microbial Natural Products and Biosynthesis"
    ]
  ],
  "openalex": "W7225076517",
  "pdf_url": "https://europepmc.org/articles/PMC13728077?pdf=render",
  "pmcid": "PMC13728077",
  "pmid": "42970221",
  "published": "2026-11-02",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/caw3kexpc3p8n.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:43Z",
      "native_id": "MED:42970221",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42970221"
    },
    {
      "first_seen": "2026-11-06T12:23:49Z",
      "native_id": "PMC13728077",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s13659-026-00637-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Microbial Natural Products and Biosynthesis",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Antioxidant metabolites from the endophytic fungus Aspergillus spelaeus.",
  "title_text": "Antioxidant metabolites from the endophytic fungus Aspergillus spelaeus.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:08Z",
  "url": "https://research.draconitic.com/paper/caw3kexpc3p8n",
  "venue": "Natural products and bioprospecting",
  "versions": []
}