{
  "abstract": "Pulmonary hypertension (PH) seems to be a rare but severe complication of Castleman disease (CD), especially the multicentric type (MCD). We report a case of recurrent fever, anemia and progressive dyspnea. She was finally diagnosed with pre-capillary PH in the setting of MCD and Epstein-Barr virus (EBV) co-infection after right heart catheterization and lymph node biopsy. After receiving siltuximab, an anti-interleukin-6 monoclonal antibody along with diuretic agent, the symptoms were relieved. However, the patient died 8 months after diagnosis due to a pulmonary hypertensive crisis secondary to clinically diagnosed bacterial pneumonia presenting with severe dyspnea, refractory hypoxemia, and acute right ventricular failure. This rare case improves recognition of this infrequent etiology of PH.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.",
    "Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.",
    "Department of Respiratory and Critical Care Medicine, The People's Hospital of Liuyang City, Liuyang, China."
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xi Yan"
    },
    {
      "affs": [
        1
      ],
      "name": "Lipin Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongrui Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Jiao Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Maoyun Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Lan Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/caz95d5hbkw89.bib",
  "cited_by": 0,
  "doi": "10.3389/fmed.2026.1951176",
  "fulltext_url": "https://europepmc.org/articles/PMC13714884",
  "id": "caz95d5hbkw89",
  "issns": [
    "2296-858X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953637",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "openalex",
      "2730|Viral-associated cancers and disorders"
    ]
  ],
  "openalex": "W7221755935",
  "pdf_url": "https://europepmc.org/articles/PMC13714884?pdf=render",
  "pmcid": "PMC13714884",
  "pmid": "42953637",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/caz95d5hbkw89.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953637",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953637"
    },
    {
      "first_seen": "2026-11-01T12:22:17Z",
      "native_id": "PMC13714884",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fmed.2026.1951176"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Viral-associated cancers and disorders",
      "subfield": "oncology"
    }
  ],
  "title": "Pulmonary hypertension in a patient with HHV-8-negative multicentric castleman disease and epstein-barr virus co-infection: a case report.",
  "title_text": "Pulmonary hypertension in a patient with HHV-8-negative multicentric castleman disease and epstein-barr virus co-infection: a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:17Z",
  "url": "https://research.draconitic.com/paper/caz95d5hbkw89",
  "venue": "Frontiers in medicine",
  "versions": []
}