{
  "abstract": "Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic metabolic liver disease worldwide, encompassing a spectrum that includes simple steatosis, metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, and hepatocellular carcinoma (HCC), with immune-metabolic-inflammatory dysregulation at its core pathogenesis. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway serves as the central axis of cytosolic DNA sensing and innate immune activation. Endogenous stimuli, including mitochondrial DNA leakage, DNA damage, and gut microbial DNA translocation, can persistently activate this pathway, which in turn regulates lipid metabolism imbalance, hepatic inflammation amplification, hepatic stellate cell (HSC) activation, and malignant transformation through downstream signaling axes, driving the full spectrum of MASLD pathology. Molecules associated with the cGAS-STING pathway may serve as non-invasive diagnostic biomarkers for MASLD, and natural compounds, traditional Chinese medicine, and nanosystems targeting this pathway have demonstrated promising therapeutic effects. This review systematically summarizes the molecular mechanisms of the cGAS-STING pathway, its regulatory roles in MASLD, and advances in targeted therapy, providing a theoretical foundation for disease mechanism elucidation and the development of diagnostic and therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine",
    "Department of Graduate Studies, Academy of Traditional Chinese Medicine",
    "Department of Nephrology, Heilongjiang Academy of Traditional Chinese Medicine"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xingxing Yuan"
    },
    {
      "affs": [
        1
      ],
      "name": "Jing Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Ying Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cb1emckwvkwdf.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1909062",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710816/",
  "id": "cb1emckwvkwdf",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1909062/full",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Mini Review"
    ],
    [
      "openalex",
      "2713|Liver Disease Diagnosis and Treatment"
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  "openalex": "W7221602558",
  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1909062/pdf",
  "pmcid": "PMC13710816",
  "pmid": "42947939",
  "published": "2026-10-13",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/cb1emckwvkwdf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1909062",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1909062/full"
    },
    {
      "first_seen": "2026-10-31T12:21:42Z",
      "native_id": "PMC13710816",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fphar.2026.1909062"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Liver Disease Diagnosis and Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The cGAS-STING pathway in metabolic dysfunction-associated steatotic liver disease: mechanistic insights and therapeutic opportunities",
  "title_text": "The cGAS-STING pathway in metabolic dysfunction-associated steatotic liver disease: mechanistic insights and therapeutic opportunities",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:42Z",
  "url": "https://research.draconitic.com/paper/cb1emckwvkwdf",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}