{
  "abstract": "During Staphylococcus aureus sepsis, the pore-forming -toxin (Hla) triggers lytic platelet death and provokes the release of catecholamines that modulate leukocyte effector function. The resulting surge in catecholaminergic action paralyzes host antimicrobial capacity by upregulating interleukin-10 (IL-10), profoundly suppressing the protective interferon (IFN) response to orchestrate innate immunoparalysis. Here, we deconvolute a multi-cellular regulatory pathway in the blood and highlight a pivotal immunological checkpoint, where pharmacological intervention with cardioselective {beta}-blockers uncouples the immunosuppressive cascade, restores host antimicrobial function, and significantly improves survival outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "University of California, San Diego"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "J. W. Sun"
    },
    {
      "name": "R. Siew"
    },
    {
      "name": "D. J. Gonzalez"
    },
    {
      "name": "B. Luna"
    },
    {
      "name": "S. Kanaji"
    },
    {
      "name": "G. Sakoulas"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cb79bvxff9125.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.12.758599",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.12.758599v1.full",
  "id": "cb79bvxff9125",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.12.758599v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ],
    [
      "openalex",
      "2713|Sepsis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7221671218",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.12.758599v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-12",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/cb79bvxff9125.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:38Z",
      "native_id": "10.64898/2026.10.12.758599",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.12.758599v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Cardioselective β-blocker Therapy Resolves Staphylococcus aureus Toxin-Induced Innate Immunoparalysis",
  "title_text": "Cardioselective β-blocker Therapy Resolves Staphylococcus aureus Toxin-Induced Innate Immunoparalysis",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:38Z",
  "url": "https://research.draconitic.com/paper/cb79bvxff9125",
  "venue": "bioRxiv",
  "versions": []
}