{
  "abstract": "Aim of the study: Intraductal papillary mucinous neoplasms (IPMNs) are among the most common cystic pancreatic neoplasms, with a potential to progress to malignancy. The increasing prevalence of IPMNs, coupled with the widespread use of GLP-1 receptor agonists (GLP-1 RAs) for diabetes and obesity management, raises concerns about the safety of these medications in patients with preexisting pancreatic conditions. Despite their proven metabolic benefits, questions remain about their impact on pancreatic pathology. This study investigates the association between GLP-1 RA use and IPMN progression to address this critical gap in the current literature. Methods: This retrospective multicentric cohort study will analyse data from January 2010 to July 2026 across three Swiss tertiary institutions. Patients with a radiological diagnosis of IPMN and/or treated with GLP-1 RAs will be included. Patients will be stratified into four groups according to a 2 × 2 design based on GLP-1 RAs exposure and IPMN status. The primary objective is to evaluate the impact of GLP-1 RAs on IPMN progression using radiological criteria from the Kyoto 2023 Consensus. Secondary objectives include assessing changes in tumour markers (CA19−9, CEA), the incidence of acute pancreatitis, the progression of IPMNs to high-grade dysplasia or invasive carcinoma, and the need for surgical intervention or altered surveillance protocols associated with GLP1 RAs use. Discussion: This study aims to explore potential associations between GLP-1 RA use and changes in IPMN characteristics, tumour markers, and disease progression. Given the retrospective design and expected small sample size (estimated at 30–60 patients in total), the study may not be powered to establish definitive correlations. Nonetheless, it will generate preliminary data to help inform hypotheses and guide future research. Any observed trends could provide valuable insights into the safety of GLP-1 RAs in patients with IPMNs and contribute to more informed clinical decision-making regarding the use of these agents in a population at risk for pancreatic disease progression. Trial registration: ClinicalTrials.gov NCT07014709",
  "abstract_shown": true,
  "affiliations": [
    "Department of Surgery, Fribourg Cantonal Hospital, Villars-sur-Glâne, Switzerland",
    "Department of Medical and Surgical Specialties, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland",
    "Direction of IT service Education and Research, University of Fribourg, Fribourg, Switzerland",
    "Department of Radiology, Fribourg Cantonal Hospital, Villars-sur-Glâne, Switzerland",
    "Hirslanden Clinics Geneva, Geneva, Switzerland",
    "Universitätsklinik für Viszerale Chirurgie und Medizin, Universität Bern, Inselspital, Bern, Switzerland",
    "Division of Digestive Surgery, University Hospitals of Geneva, Genève, Switzerland",
    "Division of Gastroenterology, University Hospitals of Geneva, Genève, Switzerland"
  ],
  "article_type": "Study Protocol",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Melissa Lagger"
    },
    {
      "affs": [
        1
      ],
      "name": "Hugo Najberg"
    },
    {
      "affs": [
        2
      ],
      "name": "Almir Miftaroski"
    },
    {
      "affs": [
        3
      ],
      "name": "Lucien Widmer"
    },
    {
      "affs": [
        4
      ],
      "name": "Sara Di Renzo"
    },
    {
      "affs": [
        5
      ],
      "name": "Pouya Iranmanesh"
    },
    {
      "affs": [
        6
      ],
      "name": "Maxime Matter"
    },
    {
      "affs": [
        7
      ],
      "name": "Boran Tekdogan"
    },
    {
      "name": "Stéphanie Perrodin"
    },
    {
      "name": "Beat Gloor"
    },
    {
      "name": "Christian Toso"
    },
    {
      "name": "Jean-Louis Frossard"
    },
    {
      "name": "Michel Adamina"
    },
    {
      "name": "Leo Buhler"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/cbbkqjjc4fsx2.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357577",
  "fulltext_url": null,
  "id": "cbbkqjjc4fsx2",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0357577",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Endocrinology/Endocrine disorders/Diabetes mellitus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Epidemiology/Cancer epidemiology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Gastroenterology and hepatology/Gastrointestinal cancers"
    ],
    [
      "plos",
      "/Medicine and health sciences/Gastroenterology and hepatology/Pancreatitis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Metabolic disorders/Diabetes mellitus"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancer treatment"
    ],
    [
      "plos",
      "/Medicine and health sciences/Oncology/Cancers and neoplasms/Gastrointestinal tumors/Pancreatic cancer"
    ],
    [
      "plos",
      "/Medicine and health sciences/Radiology and imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Diagnostic radiology/Magnetic resonance imaging"
    ]
  ],
  "openalex": "W7212056328",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357577&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-09",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/cbbkqjjc4fsx2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pone.0357577",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0357577"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:endocrinology",
      "subfield": "endocrinology-metabolism"
    },
    {
      "field": "medicine",
      "origin": "plos:diagnostic radiology",
      "subfield": "imaging"
    },
    {
      "field": "medicine",
      "origin": "plos:oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Impact of GLP-1 receptor agonists on patients with intraductal papillary mucinous neoplasms: Study protocol for a multicentric cohort study",
  "title_text": "Impact of GLP-1 receptor agonists on patients with intraductal papillary mucinous neoplasms: Study protocol for a multicentric cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/cbbkqjjc4fsx2",
  "venue": "PLOS One",
  "versions": []
}